1.北京市临床药学研究所,北京 100035
2.首都医科大学附属北京中医医院心血管内科,北京 100010
刘冬平,女,48岁,硕士,研究员。研究方向:中药药理。
刘红旭,E-mail:lhx@263.com
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刘冬平,廖磊,李蜀平,等.参元益气活血胶囊对大鼠心肌缺血再灌注损伤的影响[J].北京中医药,2022,41(2):132-135.
LIU Dong-ping,LIAO Lei,LI Shu-ping,et al.Effect of Shenyuan Yiqi Huoxue Capsule on myocardial ischemia-reperfusion injury in rats[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(02):132-135.
刘冬平,廖磊,李蜀平,等.参元益气活血胶囊对大鼠心肌缺血再灌注损伤的影响[J].北京中医药,2022,41(2):132-135. DOI: 10.16025/j.1674-1307.2022.02.005.
LIU Dong-ping,LIAO Lei,LI Shu-ping,et al.Effect of Shenyuan Yiqi Huoxue Capsule on myocardial ischemia-reperfusion injury in rats[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(02):132-135. DOI: 10.16025/j.1674-1307.2022.02.005.
目的,2,观察参元益气活血胶囊对大鼠心肌缺血再灌注损伤(MIRI)的影响。,方法,2,SD大鼠分为假手术组、模型组、复方丹参片1.26 g/kg(对照组)和参元益气活血胶囊低(1.08 g/kg)、中(2.16 g/kg)、高(4.31 g/kg)剂量组。采用大鼠结扎冠状动脉左前降支30 min,再灌注120 min制备MIRI模型,测定血清AST、LDH、CK-MB、CK、Na,+,-K,+,-ATPase、Ca,2+,-Mg,2+,-ATPase、PGI2、TX-A2、SOD、MDA水平。,结果,2,与模型组比较,参元益气活血胶囊高剂量组可明显抑制血清中AST、CK、LDH、TX-A2、MDA的释放,提高Na,+,-K,+,-ATPase、Ca,2+,-Mg,2+,-ATPase、PGI2、SOD活力(,P,<,0.01,,P,<,0.05);参元益气活血胶囊中剂量组可明显抑制血清中CK、LDH的释放,提高SOD活力(,P,<,0.01,,P,<,0.05)。,结论,2,参元益气活血胶囊对MIRI大鼠心肌具有保护作用。
Objective,2,To observe the effect of Shenyuan Yiqi Huoxue Capsule on myocardial ischemia-reperfusion injury (MIRI) in rats .,Methods,2,SD rats were randomly divided into sham,model, Compound Danshen Tablet 1.26 g/kg (control group) and Shenyuan Yiqi Huoxue Capsule groups of low dosage 1.08 g/kg, medium dosage 2.16 g/kg,and large dosage 4.31 g/kg. The MIRI model was established by the ligation of the left anterior descending coronary artery 30 min and the release 120 min in rats. Serum AST, LDH,CK-MB, CK, Na,+,-K,+,-ATPase, Ca,2+,-Mg,2+,-ATPase, PGI2, TX-A2, SOD, MDA were measured.,Results,2,Compared with the model group, Shenyuan Yiqi Huoxue Capsule group of high dosage can significantly inhibit serum AST, CK, LDH, TX-A2 and MDA content, improve Na,+,-K,+,-ATPase, Ca,2+,-Mg,2+,-ATPase, PGI2 and SOD activity(,P,<,0.01,,P,<,0.05);medium group can inhibit serum CK and LDH content, improve SOD activity (,P,<,0.01,,P,<,0.05).,Conclusion,2,Shenyuan Yiqi Huoxue Capsule has a protective effect on MIRI myocardium in rats.
参元益气活血胶囊心肌缺血再灌注损伤心肌酶大鼠
Shenyuan Yiqi Huoxue Capsulemyocardial ischemia–reperfusion injurymyocardial enzymesrat
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