参附注射液对阿霉素所致心肌毒性的保护作用研究

高宇辉; 卜雯婧; 信钰; 赵红梅; 张红凯

doi:10.16025/j.1674-1307.2022.03.010

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参附注射液对阿霉素所致心肌毒性的保护作用研究

实验研究 | 更新时间：2023-02-15

- 参附注射液对阿霉素所致心肌毒性的保护作用研究
- Protective effect of Shenfu Injection on adriamycin-induced myocardial toxicity
- 北京中医药 2022年41卷第3期页码：270-274
- 作者机构：
  
  1.首都医科大学附属北京中医医院，北京 100010
  2.中国医学科学院基础医学研究所，北京 100005
- 作者简介：
  
  高宇辉，男，48岁，博士，助理研究员。研究方向：中药防治化疗损伤。
  张红凯，E-mail：zhanghongkai@bjzhongyi.com
- 基金信息：
  
  北京市属医院科研培育计划项目(PZ2019023)
- DOI：10.16025/j.1674-1307.2022.03.010
  中图分类号：
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高宇辉，卜雯婧，信钰，等.参附注射液对阿霉素所致心肌毒性的保护作用研究［J］.北京中医药，2022，41（3）：270-274.

GAO Yu-hui,BU Wen-jing,Xin Yu,et al.Protective effect of Shenfu Injection on adriamycin-induced myocardial toxicity[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(03):270-274.
高宇辉，卜雯婧，信钰，等.参附注射液对阿霉素所致心肌毒性的保护作用研究［J］.北京中医药，2022，41（3）：270-274. DOI： 10.16025/j.1674-1307.2022.03.010.

GAO Yu-hui,BU Wen-jing,Xin Yu,et al.Protective effect of Shenfu Injection on adriamycin-induced myocardial toxicity[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(03):270-274. DOI： 10.16025/j.1674-1307.2022.03.010.

摘要

目的,2,研究参附注射液对化疗药阿霉素引起的心肌毒性的保护作用。,方法,2,大鼠心肌细胞H9c2体外培养，给予不同的药物处理，分为阿霉素、参附、参附+阿霉素，以及生理盐水的对照组，通过检测细胞凋亡、线粒体氧化损伤、活性氧（ROS）水平以及凋亡关键蛋白的变化，研究参附注射液对心肌细胞保护的分子机制。,结果,2,参附注射液可以抑制阿霉素引起的心肌细胞凋亡、减少ROS的产生、改善线粒体氧化损伤，从而起到保护作用。,结论,2,参附注射液对阿霉素引起的心脏损伤有一定的保护作用。

Abstract

Objective,2,To study the protective effect of Shenfu Injection（SFI） on cardiotoxicity caused by adriamycin chemotherapy.,Methods,2,The cardiomyocytes H9c2 cells of rat were cultured in vitro and treated with different drugs. They were divided into several treatment groups： doxorubicin groupu，SFI grouup，SFI and doxorubicin combination group，and physiological saline control group. Cell apoptosis，mitochondrial oxidative damage，ROS level and activation of apoptosis caspase-3 were evaluated to study the molecular mechanism of Shenfu injection on cardiomyocyte protection.,Results,2,SFI can significantly inhibit the cardiomyocyte apoptosis caused by doxorubicin，reduce the production of ROS，and mitigate mitochondrial oxidative injury so as to play a protective role.,Conclusion,2,SFI certainly has a certain protective effect on heart injury caused by doxorubicin.

关键词

参附注射液阿霉素心肌毒性氧化应激

Keywords

Shenfu injectionDoxorubicincardiotoxicityoxidative stress

references

CAI XY,ZENG ZY,HONG L,et al.The role of toll-like receptors in myocardial toxicity induced by doxorubicin[J].Immunol Lett,2020,217:56-64.

WOUTERS KA,KREMER LC,MILLER TL,et al.Protecting against anthracycline-induced myocardial damage:a review of the most promising strategies[J].Br J Haematol,2005,131(5):561-578.

SANTOS ARRUDA FDOS,TOMÉ FD,MIGUEL MP,et al.Doxorubicin-induced cardiotoxicity and cardioprotective agents:classic and new players in the game[J].Curr Pharm Des,2019,25(2):109-118.

SONGBO M,LANG H,XINYONG C,et al.Oxidative stress injury in doxorubicin-induced cardiotoxicity[J].Toxicol Lett,2019,307:41-48.

张红凯,卜雯静,朱庆.参附注射液防治化疗药不良反应临床疗效研究进展[J].北京中医药,2020,39(2):185-187.

屈强.参附注射液对表柔比星化疗患者心脏毒性的影响[J].肿瘤基础与临床,2012,25(3):262-263.

李田宏.蒽环类药物所致心脏毒性与中医证型相关性及中药防治的临床研究[D].沈阳:辽宁中医药大学,2019.

CORREMANS R,ADÃO R,DE KEULENAER GW,et al.Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity[J].Clin Exp Pharmacol Physiol,2019,46(3):204-215.

SONGBO M,LANG H,XINYONG C,et al.Oxidative stress injury in doxorubicin-induced cardiotoxicity[J].Toxicol Lett,2019,307:41-48.

WENNINGMANN N,KNAPP M,ANDE A,et al.Insights into doxorubicin-induced cardiotoxicity:molecular mechanisms,preventive strategies,and early monitoring[J].Mol Pharmacol,2019,96(2):219-232.

WU H,DAI Z,LIU X,et al.Pharmacodynamic evaluation of shenfu injection in rats with ischemic heart failure and its effect on small molecules using matrix-assisted laser desorption/ionization-mass spectrometry imaging[J].Front Pharmacol,2019,10:1424.

周琦,尚菊菊,来晓磊,等.参附注射液对26例充血性心力衰竭患者血流动力学的影响[J].北京中医药,2016,35(4):377-379.

CHONG SJ,LOW IC,PERVAIZ S.Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator[J].Mitochondrion,2014,19 Pt A:39-48.

JI JF,JIAO WZ,CHENG Y,et al.ShenFu preparation protects AML12 cells against palmitic acid-induced injury through inhibition of both JNK/Nox4 and JNK/NFκB pathways[J].Cell Physiol Biochem,2018,45(4):1617-1630.

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