加用芪参桃红颗粒对慢性心力衰竭疗效的影响观察

李星星; 林泉; 逯金金; 崔晓云; 李冬; 范宗静; 崔杰; 吴旸; 林谦; 李岩

doi:10.16025/j.1674-1307.2022.04.007

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加用芪参桃红颗粒对慢性心力衰竭疗效的影响观察

临床研究 | 更新时间：2023-06-16

- 加用芪参桃红颗粒对慢性心力衰竭疗效的影响观察
- Effect of added Qishen Taohong Granules on treatment of chronic heart failure
- 北京中医药 2022年41卷第4期页码：374-378
- 作者机构：
  
  1.北京中医药大学,北京 100029
  2.北京中医药大学东方医院,北京 100078
  3.北京中医药大学东直门医院,北京 100700
- 作者简介：
  
  李星星，女，27岁，博士研究生。研究方向：中西医结合防治心血管病。
  李岩，E-mail：erzitaba@163.com
- 基金信息：
  
  国家自然科学基金面上项目(81973622);北京市科学技术委员会资助项目(Z171100001017225);北京中医药大学东方医院1166人才工程项目(030903010331)
- DOI：10.16025/j.1674-1307.2022.04.007
  中图分类号：
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李星星，林泉，逯金金，等.加用芪参桃红颗粒对慢性心力衰竭疗效的影响观察［J］.北京中医药，2022，41（4）：374-378.

LI Xing-xing,LIN Quan,LU Jin-jin,et al.Effect of added Qishen Taohong Granules on treatment of chronic heart failure[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(04):374-378.
李星星，林泉，逯金金，等.加用芪参桃红颗粒对慢性心力衰竭疗效的影响观察［J］.北京中医药，2022，41（4）：374-378. DOI： 10.16025/j.1674-1307.2022.04.007.

LI Xing-xing,LIN Quan,LU Jin-jin,et al.Effect of added Qishen Taohong Granules on treatment of chronic heart failure[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(04):374-378. DOI： 10.16025/j.1674-1307.2022.04.007.

摘要

目的,2,观察加用芪参桃红颗粒对慢性心力衰竭（CHF）患者利尿剂停减率和再住院率的影响。,方法,2,采用前瞻性、随机、对照临床试验方法，将103例CHF患者随机分为观察组和对照组。2组均予西医常规治疗，观察组在此基础上加用芪参桃红颗粒，对照组加用盐酸曲美他嗪，疗程均为4周。评价2组患者治疗前后心功能（NYHA分级）、利尿剂停减率和再住院率的变化，并对芪参桃红颗粒治疗CHF进行安全性评价。,结果,2,治疗4周后，观察组NYHA心功能分级总有效率76.2%、对照组为58.8%，2组间差异有统计学意义（,P<,0.05）；观察组患者的利尿剂停减率为80.00%、对照组52.94%，2组间差异有统计学意义（,P,<,0.05）。入组24周后，观察组和对照组患者再住院率分别为33.33%和46.34%。2组患者在治疗期间均未发生明显不良反应。,结论,2,芪参桃红颗粒可改善CHF患者的心功能，提高利尿剂停减率，降低再住院率。

Abstract

Objective,2,To observe the effect of added Qishen Taohong Granules on treatment of patients with chronic heart failure （CHF）.,Methods,2,Using prospective，randomized，controlled clinical trial methods，103 CHF patients were randomly divided into treatment group and control group. Both groups were treated with conventional western medicine. On this basis，the treatment group was treated with Qishen Taohong Granules and the control group was treated with trimetazidine hydrochloride for 4 weeks. The changes in cardiac function （NYHA classification），diuretic discontinuation rate and rehospitalization rate of the two groups of patients before and after treatment were evaluated，and the safety of Qishen Taohong Granules in the treatment of chronic heart failure was evaluated.,Results,2,After 4 weeks of treatment，the total effective rate of NYHA cardiac function classification in the treatment group was 76.2%，and that of the control group was 58.8%，and the difference of two groups were statistically significant（,P,<,0.05）；the diuretic discontinuation rate of patients in the treatment group was 80.00% and the control group was 52.94 %，there was a statistical difference between the two groups （,P,<,0.05）. After 24 weeks of enrollment，the rehospitalization rate of patients in the treatment group and the control group were 33.33% and 46.34% respectively. There were no obvious adverse events in the two groups during the treatment.,Conclusion,2,Qishen Taohong Granules can improve the cardiac function，increase the diuretic discontinuation rate and reduce the rehospitalization rate of patients with chronic heart failure.

关键词

芪参桃红颗粒慢性心力衰竭利尿剂停减率再住院率

Keywords

Qishen Taohong Granuleschronic heart failurediuretic discontinuation raterehospitalization rate

references

BAMAN JR, AHMAD FS. Heart failure[J].JAMA， 2020,324(10):1015.

DHARMARAJAN K,RICH MW.Epidemiology,pathophysiology,and prognosis of heart failure in older adults[J].Heart Fail Clin,2017,13(3):417-426.

GOLDGRAB D,BALAKUMARAN K,KIM MJ,et al.Updates in heart failure 30-day readmission prevention[J].Heart Fail Rev. 2019,24(2):177-187.

国家卫生计生委合理用药专家委员会,中国药师协会.心力衰竭合理用药指南(第2版)[J].中国医学前沿杂志(电子版),2019,11(7):1-78.

IQBAL J,JAVAID MM.Diuretic resistance and its management[J].Br J Hosp Med Lond,2014,75(7):C103-C107.

陈可冀,吴宗贵,朱明军,等.慢性心力衰竭中西医结合诊疗专家共识[J].中国中西医结合杂志,2016,36(2):133-141.

佟彤,周琦,来晓磊,等.芪葶利水方对冠心病心力衰竭患者临床疗效、生活质量及血清基质金属蛋白酶的影响[J].北京中医药,2020,39(7):674-678.

王咏,徐基节,刘永明,等.复方鹿角合剂治疗慢性心力衰竭的随机双盲对照研究[J].上海中医药大学学报,2016,30(4):12-17.

杨聪,郑刚,齐婧,等.中西医结合对慢性心力衰竭伴利尿剂抵抗疗效及客观指标影响的meta分析[J].中国中医急症,2021,30(1):27-31.

张国权,李岩,林谦.益气活血利水方治疗心衰病气虚血瘀水停证的临床研究[J].中西医结合心脑血管病杂志,2020,18(19):3148-3152.

张健,张宇辉.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98-122.

HUNT SA,ABRAHAM WT,CHIN MH,et al.2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults[J].J Am Coll Cardiol,2009,53(15):e1-e90. doi:10.1016/j.jacc.2008.11.013http://dx.doi.org/10.1016/j.jacc.2008.11.013.

亓鹏,张朝香.ACC/AHA2009成人心力衰竭诊断与治疗最新指南简介(一)[J].中华保健医学杂志,2010,12(4):323-325.

郑筱萸.中药新药临床研究指导原则( 试行)[M].北京:中国医药科技出版社,2002:77-85.

高京华,李红文,孙媛,等.延续护理对老年慢性心衰患者6分钟步行实验及再住院率的影响研究[J].中国护理管理,2017,17(5):668-671.

邵笑,邓悦.气血津液理论在心血管疾病中的应用研究进展[J].中西医结合心脑血管病杂志,2020,18(17):2801-2803.

李星星,吴旸,林泉,等.益气活血利水方辅助治疗慢性心力衰竭气虚血瘀水停证的随机对照试验[J].中医杂志,2019,60(20):1741-1746.

李岩，农一兵，林谦.益气药对慢性心力衰竭心气虚证模型大鼠总肌酸激酶活性、肌酸激酶同工酶及腺苷酸转位酶mRNA表达的影响［J］.中华中医药杂志，2011，26（5）：1216-1221.

李思耐,林谦,高群,等.黄芪党参对心肌梗死后心衰小鼠心肌复极时间的干预研究[J].中国中西医结合杂志,2018,38(2):232-236.

靳嘉麟.基于mTOR/自噬通路探讨芪参桃红颗粒对心衰小鼠心肌重构干预的研究[D].北京:北京中医药大学,2020.

邱志凌,朱宝琛,李琪琳.中医药防治心力衰竭的现状研究[J].北京中医药,2021,40(6):566-570.

冯雨菲,何贵新,胡梦弦,郑国坤,玉黎燕.从线粒体功能障碍辩谈心病及中药复方干预治疗研究进展[J/OL].辽宁中医药大学学报:1-11[2021-11-10].http://kns.cnki.net/kcms/detail/21.1543.R.20210916.1113.014.htmlhttp://kns.cnki.net/kcms/detail/21.1543.R.20210916.1113.014.html.

孙利军.美托洛尔联合曲美他嗪治疗冠心病合并心衰的疗效[J].实用中西医结合临床,2020,20(1):138-139,141.

陶志悦.盐酸曲美他嗪胶囊对慢性心力衰竭患者心功能的影响[D].南宁:广西中医药大学,2017.

FELKER GM, ELLISON DH, MULLENS W, et al.Diuretic therapy for patients with heart failure: jacc state-of-the-art review[J].J Am Coll Cardiol.2020,75(10):1178-1195.

任耀龙,王永刚,崔淑兰,等.补气药利尿与抗利尿作用及其临床配伍应用[J].辽宁中医药大学学报,2014,16(7):101-103.

石磊,叶巍,刘果果.中医药在慢性心力衰竭患者中的应用进展分析[J].中国医药科学,2020,10(14):47-50.

罗良涛,王娟,赵慧辉,等.17家中医医院慢性心力衰竭患者临床特征及治疗情况调查[J].中国中西医结合杂志,2014,34(6):754-757.

WEI HY,DING LM,WANG XJ,et al.Astragalus root extract improved average daily gain, immunity, antioxidant status and ruminal microbiota of early weaned yak calves[J].J Sci Food Agric.2021,101(1):82-90.

FU YP,FENG B,ZHU ZK,et al.The polysaccharides from Codonopsis pilosula modulates the immunity and intestinal microbiota of cyclophosphamide-treated immunosuppressed mice[J].Molecules,2018,23(7):1801.

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