Objective,2,To discuss the influence of different processing methods on the content of the liquidambaric acid in Fructus Liquidambris pieces.,Methods,2,A total of 500 g original medicinal slices of Fructus Liquidambris were divided into 5 equal parts， and then processed according to the methods used in Beijing， Fujian， Shanghai， Hubei and Jiangxi with five local processing specifications respectively， and the content of liquidambaric acid in Fructus Liquidambris pieces was determined by HPLC-ELSD.,Results,2,Methodological verification results showed that there was a good linear relationship between the injection amount of Liposolic acid and the peak area in the range of 0.822 ~ 4.108 μg.The RSD of repeatability experiment was 1.02%. The RSD of stability experiment was 0.45%. The average addition recovery was 99.19% and RSD was 1.91%（,n,=6）.And the detection method had good accuracy， repeatability and stability. According to five different processing methods in Beijing， Fujian， Shanghai， Hubei and Jiangxi， the contents of Liquidambaric acid in the prepared pieces were 0.268 6%， 0.272 8%， 0.241 7%， 0.270 6% and 0.239 0%， respectively ， which met the requirements of pharmacopoeia.,Conclusion,2,The contents of Lipuidambaric acid in different processed pieces of Lipuidambaric acid meet the requirements of Pharmacopoeia. The content of the liquidambaric acid in Fructus Liquidambris decoction pieces processed with processing method of Fujian was the highest （0.272 8%）， and the content of the liquidambaric acid in Fructus Liquidambris decoction pieces processed with processing method of Jiangxi was the lowest （0.239 0%）.