Objective,2,To observe the therapeutic effect and mechanism of Tongxie Yaofang combined with Sini powder on diabetes mellitus.,Methods,2,24 KK⁃Ay mice were randomly divided into model group and low， medium and high dose Chinese medicine treatment groups respectively of 6 mice in each group， and another 6 C57BL/6J mice were taken as blank control group. The low， middle and high dose groups were given the crude dosage of Chinese medicine 1.84， 3.68 and 5.52 g/（kg d） respectively， while the blank group and model group were given the same volume of distilled water once a day for 4 weeks. The changes of body mass， fasting blood glucose （FBG）， insulin （INS）， insulin resistance index （HOMA⁃IR） and corticosterone （CORT） in each group were compared. The expression levels of 11β hydroxysteroid dehydrogenase ⅰ （HSD1） and glucocorticoid receptor （GR） in hippocampus were detected by Western blotting.,Results,2,Compared with the blank group， the body mass of the model group was higher at the 0，1，2，3 and 4 weeks of intervention （,P,<,0.05）. Compared with the model group， the body weight of the low， medium and high dose groups was lower in the first and second weeks of intervention （,P,>,0.05）. At the 3rd and 4th week， the body weight of the low， middle and high dose groups was low （,P,<,0.05）. Compared with the blank group， the FBG in the model group was higher at the 0，1，2，3 and 4 weeks of intervention （,P,<,0.05）. Compared with the model group， the level of FBG in the low， middle and high dose groups was lower at the 0， 1， 2 and 3 weeks of intervention （,P,>,0.05）. At the 4th week， the level of FBG in the high dose group was low （,P,<,0.05）. Compared with the blank group， the INS level and HOMA⁃IR in the model group were higher （,P,<,0.05）. Compared with the model group， the INS level and HOMA⁃IR in the low-dose group were lower， with no statistical significance （,P,>,0.05）. The levels of INS and HOMA⁃IR in middle and high dose groups were lower， and the difference was statistically significant （,P,<,0.05）. Compared with the model group， the CORT level in the low-dose group was lower， and the difference was not statistically significant （,P,>,0.05）. CORT in middle and high dose groups was lower， and the difference was statistically significant （,P,<,0.05）. Compared with the blank group， the expression of 11β⁃HSD1 protein in hippocampus of model group was higher， while the expression of GR protein was lower， with statistical significance （,P,<,0.05）. Compared with the model group， the expression of 11β⁃HSD1 protein in hippocampus of the low-dose group was lower， while the expression of GR protein was higher， with no statistical significance （,P,>,0.05）. The expression of 11β-HSD1 protein in hippocampus was low and GR protein was high in middle and high dose groups， and the difference was statistically significant （,P,<,0.05）.,Conclusion,2,Tongxie Yaofang combined with Sini Powder can decrease the level of FBG and improve insulin resistance in type 2 diabetes mice， and its mechanism may be related to the reduction of corticosterone content and the regulation of 11β-HSD1 and GR protein expression.