Objective

2

To verify the clinical efficacy and safety of self-made Ruhe Powder Gel.

Methods

2

A total of 300 patients with benign tumors and breast nodules mainly characterized by lobular proliferative masses of the breast who underwent minimally invasive ablation were admitted to Shanghai Traditional Chinese Medicine Hospital from July 2018 to July 2021 were selected，among whom， 150 patients were treated with minimally invasive ablation and 150 patients were not treated with minimally invasive ablation. According to the random number table， the patients who underwent ablation were divided into treatment group 1 and control group 1， and the patients who did not receive minimally invasive ablation were divided into treatment group 2 and control group 2. The treatment group was given Ruhe Powder Gel for external application on the affected breast， and the control group was given external application of Mammalin Paste for 2 consecutive courses， all once a day and 30 days as one course. The curative effect， visual analogue scale （VAS） score， symptoms and signs score， the maximum diameter， volume and adverse reactions of nodules were compared between the two groups.

Results

2

The total effective rate of treatment group 1 was higher than that of control group 1 （

P

<

0.05）， and that of treatment group 2 was higher than that of control group 2 （

P

<

0.05）. Compared with before treatment， the VAS scores of each group decreased at the end of the first and second courses （

P

<

0.05）. At the end of the first and second courses， the VAS scores of the treatment group were lower than those of the control group （

P

<

0.05）. Compared with before treatment， at the end of the first and second courses， the scores of breast pain and total scores in each group were decreased （

P

<

0.05）. At the end of the second course of treatment， the integral of breast lump in each group decreased （

P

<

0.05）. At the end of the first and second courses， the score and total score of breast pain in the treatment group were lower than those in the control group （

P

<

0.05）. Compared with before treatment， the maximum diameter and volume of breast nodules in treatment group 1 and control group 1 were reduced at the end of the first and second courses of treatment （

P

<

0.05）. At the end of the first and second courses of treatment， the maximum diameter and volume of nodules in treatment group 1 were smaller than those in control group 1 （

P

<

0.05）. During the treatment， there were no serious adverse reactions in each group. In the control group， 1 case had slight redness and itching in the local skin， 3 cases were slightly allergic to the patch， and itching and a little herpes appeared in the application site. The symptoms were improved after topical application of Clyde cream.

Conclusion

2

The new "Ruhe Powder" Gel has good clinical efficacy in improving the clinical symptoms of patients with lobular hyperplasia of breast and could promote the absorption of breast masses after surgery， and is safe for clinical use.