ONO Y,FUKAYA Y,IMAI S,et al.Beneficial effects of Ajuga decumbens on osteoporosis and arthritis[J].Biol Pharm Bull,2008,31(6):1199-1204.

SAWADA Y,SUGIMOTO A,OSAKI T,et al.Ajuga decumbens stimulates mesenchymal stem cell differentiation and regenerates cartilage in a rabbit osteoarthritis model[J].Exp Ther Med,2018,15(5):4080-4088.

WANG H,TENG X,ZHANG Y,et al.Diterpenoids from the whole plants of Ajuga nipponensis and their inhibition of RANKL-induced osteoclastogenesis[J].Chem Biodivers,2021,18(1):e2000780.

KAYANI WK,DILSHAD E,AHMED T,et al.Evaluation of Ajuga bracteosa for antioxidant,anti-inflammatory, analgesic, antidepressant and anticoagulant activities[J].BMC Complement Altern Med,2016,16(1):375.

TOIU A,MOCAN A,VLASE L,et al.Phytochemical composition,antioxidant,antimicrobial and in vivo anti-inflammatory activity of traditionally used romanian Ajuga laxmannii(Murray)Benth.("Nobleman's Beard"-Barba Împăratului)[J]. Front Pharmacol,2018,9:7.

DONG B,YANG X,LIU W,et al.Anti-inflammatory neo-clerodane diterpenoids from Ajuga pantantha[J].J Nat Prod,2020,83(4):894-904.

LIU W,SONG Z,WANG H,et al.Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha[J].Bioorg Chem,2020,101:103966.

WANG Y,LIU YC,LI WY,et al.Antifeedant,cytotoxic,and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii[J].Phytochemistry,2021,186:112731.

LV H,LUO J,KONG L.A new neo-clerodane diterpene from Ajuga decumbens[J].Nat Prod Res,2014,28(3):196-200.

ZHANG H,REN QC,REN Y,et al.Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation[J].Pharm Biol,2018,56(1):649-657.

YOU Y,WANG J,TONG Y,et al.Anti-inflammatory effect of acetylharpagide demonstrated by its influence on leukocyte adhesion and transmigration in endothelial cells under controlled shear stress[J].Clin Hemorheol Microcirc,2014,56(3):205-217.

ZHANG Z,WANG Y,SHAN Y,et al.Acetylharpagide protects mice from staphylococcus Aureus-induced acute lung injury by inhibiting NF-κB signaling pathway[J].Molecules,2020,25(23)：5523.

ZHANG L,FENG L,JIA Q,et al.Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro[J].Bioorg Med Chem,2011,19(16):4882-4886.

WANG S,CAO M,XU S,et al.Luteolin Alters macrophage polarization to inhibit inflammation[J].Inflammation,2020,43(1):95-108.

ZUO T,YUE Y,WANG X,et al.Luteolin relieved DSS-induced colitis in mice via HMGB1-TLR-NF-κB signaling pathway[J].Inflammation,2021,44(2):570-579.

TAKASAKI M,TOKUDA H,NISHINO H,et al.Cancer chemopreventive agents(antitumor-promoters)from Ajuga decumbens[J].J Nat Prod,1999,62(7):972-975.

KONOSHIMA T,TAKASAKI M,TOKUDA H,et al.Cancer chemopreventive activity of an iridoid glycoside,8-acetylharpagide,from Ajuga decumbens[J].Cancer Lett,2000,157(1):87-92.

彭博,贺蓉,徐启华,等.筋骨草提取物抑制乳腺癌转移与MMPs和TIMPs表达的关系研究[J].中国中药杂志,2011,36(24):3511-3514.

彭博,贺蓉,韩靖雅,等.筋骨草总环烯醚萜对乳腺癌干细胞特性的干预作用及其机制分析[J].中国实验方剂学杂志,2017,23(18):94-99.

彭博,杨依霏,王晶晶,等.筋骨草总环烯醚萜对三阴性乳腺癌转移的抑制作用及其机制研究[J].中国药学杂志,2017,52(21):1903-1908.

LIN YT,LIN CC,WANG HC,et al.Induction of mitotic delay in pharyngeal and nasopharyngeal carcinoma cells using an aqueous extract of Ajuga bracteosa[J].Int J Med Sci,2017,14(5):462-469.

姜琼,夏松柏,梅同荷,等.白毛夏枯草提取物对肝癌细胞增殖的抑制作用及机制研究[J].中国医院药学杂志,2016,36(20):1770-1773.

ZACCHAEUS OLATUNDE O,YONG JP,LU CZ.New neo-clerodane diterpenoids isolated from Ajuga decumbens thunb,planted at pingtan island of Fujian province with the potent anticancer activity[J].Anticancer Agents Med Chem,2023,23(2):237-244.

CHIOU CT,KUO YH,CHAN YY,et al.Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro[J].Phytochemistry,2012,80:64-69.

YANG F,CHEN HP,SHEN XF,et al.A new abietane diterpenoid glycoside from ajuga ovalifolia var. calantha[J].Nat Prod Res,2019,33(19):2856-2859.

马志平,黄榕.筋骨草有效部位黄酮类粗品的保肝试验[J].海峡药学,2002,14(5):40-41.

HSIEH CW,KO WC,HO WJ,et al.Antioxidant and hepatoprotective effects of Ajuga nipponensis extract by ultrasonic-assisted extraction[J].Asian Pac J Trop Med,2016,9(5):420-425.

曾春晖,杨柯,徐明光,等.金疮小草醇提物活血化瘀及抗急性肝损伤作用[J].中国实验方剂学杂志,2011,17(17):209-212.

NAZER S,ANDLEEB S,ALI S,et al.Cytotoxicity,anti-diabetic,and hepato-protective potential of Ajuga bracteosa-conjugated silver nanoparticles in Balb/c mice[J].Curr Pharm Biotechnol,2022,23(3):318-336.

TOIU A,MOCAN A,VLASE L,et al.Comparative phytochemical profile,antioxidant, antimicrobial and in vivo anti-inflammatory activity of different extracts of traditionally used romanian ajuga genevensis L. and A. reptans L.(Lamiaceae)[J].Molecules,2019,24(8)：1597.

HAFEEZ K,ANDLEEB S,GHOUSA T,et al.Phytochemical screening, Alpha-glucosidase inhibition,antibacterial and antioxidant potential of Ajuga bracteosa extracts[J].Curr Pharm Biotechnol,2017,18(4):336-342.

MEDJELDI S,BOUSLAMA L,BENABDALLAH A,et al.Biological activities, and phytocompounds of northwest Algeria Ajuga iva (L) extracts: Partial identification of the antibacterial fraction[J].Microb Pathog,2018,121:173-178.

RUBNAWAZ S,OKLA MK,AKHTAR N,et al.Antibacterial,antihemolytic,cytotoxic,anticancer,and antileishmanial effects of ajuga bracteosa transgenic plants[J].Plants(Basel),2021,10(9)：1894.

管敏,张力文,徐致远,等.白毛夏枯草对金黄色葡萄球菌的作用规律及抗菌机理[J].中成药,2017,39(11):2393-2396.

ALENE M,ABDELWUHAB M,BELAY A,et al.Evaluation of antidiabetic activity of Ajuga integrifolia(Lamiaceae)root extract and solvent fractions in mice[J].Evid Based Complement Alternat Med,2020,2020:6642588.

TAFESSE TB,HYMETE A,MEKONNEN Y,et al.Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota benth on alloxan-induced diabetic mice[J].BMC Complement Altern Med,2017,17(1):243.

文婷,皮建辉,谭娟,等.筋骨草提取物抗运动疲劳的作用[J].中国应用生理学杂志,2016,32(3):245-249.

楼晓慧,南丽红,彭卫华,等.筋骨草总黄酮对单侧输尿管梗阻模型大鼠肾间质纤维化的抑制作用[J].福建中医药,2022,53(6):34-37.

应雄,赖文芳,许力伟,等.筋骨草总黄酮抗小鼠肝纤维化的作用机制[J].福建中医药,2016,47(5):13-15.

邓鑫,王澍青,窦丹,等.清热化湿祛瘀方对轻中度溃疡性结肠炎患者肠道菌群的影响[J].北京中医药,2022,41(9):963-967.

管敏,周琴妹.筋骨草对小鼠慢性气道炎症改善及其对肠道菌群调节作用的研究[J].中华中医药学刊,2020,38(9):49-52,后插2-4.

JOHNSON JL,JONES MB,COBB BA.Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation[J].Glycobiology,2018,28(1):50-58.

温彬宇,李建荣.HPLC-ELSD同时测定筋骨草药材中乙酰哈巴苷和哈巴苷含量[J].中国中医药信息杂志,2014,21(7):89-92.

WEN B,HE R,LI P,et al.Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats[J].J Ethnopharmacol,2013,147(2):503-508.

温彬宇,李建荣.筋骨草提取物有效成分在beagle犬体内药代动力学研究[J].中国中药杂志,2013,38(12):2015-2018.

刘德文,张毅,李德凤,等.8-乙酰哈巴苷大鼠体内药代动力学[J].中国实验方剂学杂志,2011,17(20):129-132.

常瑞蕊,陈卫东,周婷婷.肠道菌群调控对药动学特征的影响[J].中国药学杂志,2019,54(15):1211-1215.