Objective,2,To observe the therapeutic effect of self-designed Bushen Quban Decoction on patients with chloasma and explore its possible mechanism of action.,Method,2,114 female patients with chloasma who were admitted to the People's Hospital of Kaizhou District， Chongqing from February 2018 to June 2020 were selected. The patients were randomly divided into a control group and an observation group， with 57 patients in each group using a random number table method. The control group received routine western medicine treatment， while the observation group received self-designed Bushen Quban Decoction on the basis of the control group. Both groups had a treatment course of 6 months. The efficacy， syndrome score before and after treatment， serum oxidative stress indicators （superoxide dismutase， malondialdehyde）， serum melanotropin， quality of life score， TLRs/MYD88 signal pathway related genes （TLR2， TLR4， MYD88） expression and adverse reactions were compared between the two groups.,Results,2,The total effective rate of the observation group was higher than that of the control group （,P,<,0.05）. After treatment， the main and secondary syndrome scores of the two groups were decreased compared to before treatment （,P,<,0.05）， and the main and secondary syndrome scores of the observation group were lower than those of the control group （,P,<,0.05）. After treatment， the level of superoxide dismutase in the two groups was higher than that before treatment， and the level of malondialdehyde was lower than that before treatment （,P,<,0.05）， and the level of superoxide dismutase in the observation group was higher than that in the control group， and the level of malondialdehyde was lower than that in the control group （,P,<,0.05）. After treatment， the serum levels of melatonin and quality of life in the two groups were lower than before treatment （,P,<,0.05）， and the serum levels of melatonin and quality of life in the observation group were lower than those in the control group （,P,<,0.05）. After treatment， the expression of TLR2， TLR4， and MYD88 genes in the two groups was lower than before treatment （,P,<,0.05）， and the expression of TLR2， TLR4， and MYD88 genes in the observation group was lower than that in the control group （,P,<,0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups（,χ,2,=0.438，,P,>,0.05）。,Conclusion,2,Self formulated Bushen Quban Decoction can improve the therapeutic effect of western medicine on melasma， alleviate oxidative stress response， lower serum melanotropin levels， and improve patient quality of life. Its mechanism of action may be related to down-regulating the expression of TLR2， TLR4， and MYD88 signaling pathway related genes in TLRs/MYD88.