Objective,2,To explore the clinical effect of Tianwang Buxin Dan and Guizhi Gancao Longgu Muli Decoction in treating ventricular premature beats due to deficiency of both qi and yin.,Methods,2,Sixty cases of ventricular premature beats who were diagnosed from January 2018 to December 2020 were enrolled， and they were divided into treatment group and control group by random number table. The control group was treated with metoprolol tartrate 12.5 mg or 25 mg each time， twice a day，and the treatment group was treated with Tianwang Buxin Dan and Guizhi Gancao Longgu Muli Decoction on the basis of the control group one bag each day. The course of treatment was four weeks in both groups. The curative effect of premature ventricular contractions， Myerburg grading， curative effect of TCM syndrome， the number of premature ventricular contractions before and after treatment， the related indexes of heart rate variability ［standard deviation （SDNN） of all normal RR intervals， root mean square value （rMSSD） of the difference between adjacent RR intervals， the percentage of the number of adjacent RR intervals exceeding 50 ms to the total number of sinus beats （PNN50）］ ， bigeminal beats and trigeminal beats， paired premature ventricular contractions， TCM syndrome integral and safety were compared between the two groups.,Results,2,The total effective rate of premature ventricular contraction in the treatment group was higher than that in the control group （,P,<,0.05）. After treatment， the number of premature ventricular contractions in both groups decreased （,P,<,0.05）， and the number in the treatment group was less than that in the control group （,P,<,0.05）. After treatment， the levels of SDNN， rMSSD and PNN50 in both groups were higher than that before treatment （,P,<,0.05）， and the treatment group was better than the control group （,P,<,0.05）. After treatment， bigeminal beats and trigeminal beats and the number of paired premature ventricular contractions were decreased compared with that before treatment （,P,<,0.05），in the treatment group， the number of bigeminal beats and trigeminal beats was less than that in the control group （,P,<,0.05）.The overall effective rate of Myerburg grade in the treatment group was higher than that in the control group， and the difference was statistically significant （,P,<,0.05）. After treatment， the scores of TCM syndrome in both groups were lower than those before treatment （,P,<,0.05）， and the treatment group was lower than that of the control group （,P,<,0.05）. There were no adverse events in either group.,Conclusion,2,Tianwang Buxin Dan combined with Guizhi Longgu Muli Decoction are more effective than western medicine used only in the treatment of ventricular premature beats without increasing the incidence of adverse events.