1.北京中医药大学临床医学院,北京 100029
2.首都医科大学附属北京中医医院疮疡血管外科,北京 100010
郭敬拙,女,26岁,硕士研究生。研究方向:糖尿病足溃疡的临床诊治。
徐旭英,E-mail:xxying7341@126.com
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郭敬拙,杜志欣,徐旭英.糖尿病足患者中医证型与检验指标的相关性研究[J].北京中医药,2023,42(6):685-688.
GUO Jing-zhuo,DU Zhi-xin,XU Xu-ying.Study on correlation between TCM syndrome types and test indicators in patients with diabetic foot[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(06):685-688.
郭敬拙,杜志欣,徐旭英.糖尿病足患者中医证型与检验指标的相关性研究[J].北京中医药,2023,42(6):685-688. DOI: 10.16025/j.1674-1307.2023.06.025.
GUO Jing-zhuo,DU Zhi-xin,XU Xu-ying.Study on correlation between TCM syndrome types and test indicators in patients with diabetic foot[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(06):685-688. DOI: 10.16025/j.1674-1307.2023.06.025.
目的,2,分析糖尿病足(diabetic foot,DF)患者中医证型与检验指标的关系。,方法,2,选择2019年1月—2021年12月首都医科大学附属北京中医医院疮疡血管外科住院的DF患者177例,调取其电子病历,收集数据做回顾性分析,采用Spearman检验各证型与检验指标的相关性。,结果,2,177例患者中气虚血瘀证86例(48.6%)、湿热壅盛证54例(30.5%)、气阴两虚证37例(20.9%)。各证型患者年龄、性别及周围血管病(PAD)、周围神经病(DFN)、糖尿病肾病(DR)、糖尿病视网膜病变(DN)比例比较,差异无统计学意义(,P,>,0.05)。各证型患者2型糖尿病病程比较差异有统计学意义(,P,<,0.05),气虚血瘀证患者2型糖尿病病程短于气阴两虚证患者(,P,<,0.05)。各证型患者ACE比较差异有统计学意义(,P,<,0.05),且湿热壅盛证,<,气虚血瘀证,<,气阴两虚证,湿热壅盛证患者ACE低于气阴两虚证患者,差异有统计学意义(,P,<,0.05);各证型其他指标LDH-L、CK、CKMB、ALP、BNP、ALT、AST、GGT、TBIL、Cr、UA、UREA比较,差异无统计学意义(,P,>,0.05)。证型与CK、ACE、Cr、UA呈正相关(,r,分别为0.155、0.206、0.166、0.152,,P,<,0.05)。,结论,2,DF患者中医证型中气虚血瘀证最常见;湿热壅盛证患者ACE水平最低,气阴两虚证患者的Cr水平最高。
Objective,2,To analyze the correlation between TCM syndrome types and test indicators in patients with diabetic foot (DF),.,Methods,2,The medical records of 177 DF inpatients in the Department of Ulcer Vascular Surgery, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University hospitalized from January 2019 to December 2021 were collected and retrospectively analyzed,and the correlation between each syndrome type and test index was analyzed by Spearman correlation.,Results,2,Among the 177 patients, 86 cases (48.6%) had Qi deficiency and blood stasis syndrome, 54 cases (30.5%) had excessive damp-heat syndrome, 37 cases of deficiency of both Qi and Yin, accounting for 20.9%. There was no significant difference in age, sex and the proportion of peripheral vascular disease (PAD), peripheral neuropathy (DFN), diabetic nephropathy (DR) and diabetic retinopathy (DN) among the patients of each syndrome type (,P,>,0.05). There was significant difference in the disease course of type 2 diabetes in patients with different syndromes (,P,<,0.05), and the course of type 2 diabetes in patients with Qi deficiency and blood stasis syndrome was shorter than that in patients with deficiency of both Qi and Yin (,P,<,0.05). There were significant differences in ACE among patients with different syndromes (,P,<,0.05), and the excess of damp-heat syndrome ,<, Qi deficiency and blood stasis syndrome ,<, deficiency of both Qi and Yin, and the ACE of patients with excess of damp-heat syndrome was lower than that of patients with deficiency of both Qi and Yin, with statistical significance (,P,<,0.05). There was no significant difference in LDH-L, CK, CKMB, ALP, BNP, ALT, AST, GGT, TBIL, Cr, UA and UREA among the syndromes (,P,>,0.05). Syndrome types were positively correlated with CK, ACE, Cr and UA (r were 0.155, 0.206, 0.166 and 0.152, respectively, ,P,<,0.05),.,Conclusion,2,Among DF TCM syndromes,Qi deficiency and blood stasis syndrome is the most common. Patients with excessive dampness and heat syndrome have the lowest ACE level,while patients with deficiency of Qi and Yin syndrome have the highest Cr level.
糖尿病足肌酐血管紧张素转化酶中医证型
Diabetic footcreatinineangiotensin converting enzymeTCM syndrome type
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