基于肿瘤干细胞诱导多核型髓源抑制性细胞形成介导免疫逃逸探讨中医扶正解毒法防治肿瘤转移的可能机制
Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells
- 北京中医药 2023年42卷第7期 页码：782-785
- 作者机构：
1.中国中医科学院广安门医院肿瘤科，北京 100053
- 作者简介：
毛启远，男，28岁，博士研究生。研究方向：中西医结合防治恶性肿瘤。
王学谦，E-mail：wxq791875354@126.com
- 基金信息：国家自然科学基金青年项目(82004179);“优秀青年科技人才（创新类）”培养专项(ZZ14-YQ-013);北京市科学技术协会-青年人才托举工程项目(BYESS2023357);国家自然科学基金青年项目(82104656)
DOI：10.16025/j.1674-1307.2023.07.021
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毛启远，张英，李道睿，等.基于肿瘤干细胞诱导多核型髓源抑制性细胞形成介导免疫逃逸探讨中医扶正解毒法防治肿瘤转移的可能机制［J］.北京中医药，2023，42（7）：782-785.
MAO Qi-yuan,ZHANG Ying,LI Dao-rui,et al.Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(07):782-785.
毛启远，张英，李道睿，等.基于肿瘤干细胞诱导多核型髓源抑制性细胞形成介导免疫逃逸探讨中医扶正解毒法防治肿瘤转移的可能机制［J］.北京中医药，2023，42（7）：782-785. DOI： 10.16025/j.1674-1307.2023.07.021.
MAO Qi-yuan,ZHANG Ying,LI Dao-rui,et al.Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(07):782-785. DOI： 10.16025/j.1674-1307.2023.07.021.
摘要
多核型髓源抑制性细胞（PMN-MDSCs）在肿瘤的免疫逃逸中扮演重要角色，尤其体现在逃逸T淋巴细胞免疫监视方面。肿瘤干细胞具有病理性活化中性粒细胞（PMNs）诱导PMN-MDSCs形成的能力，进而在PMN-MDSCs的帮助下实现免疫逃逸发生转移。中医扶正解毒法对PMN-MDSCs的活化形成及肿瘤干细胞的生物学行为均具有一定的调控作用，这可能为中医药防治肿瘤转移提供了新的依据。基于肿瘤干细胞诱导PMN-MDSCs形成而逃避免疫监视，探讨中医扶正解毒法干预肿瘤转移的可能机制，以期为中医药防治肿瘤转移提供新思路。
Abstract
关键词
肿瘤干细胞多核型髓源抑制性细胞免疫逃逸肿瘤转移中医扶正解毒
Keywords
references
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