Objective,2,To explore the impact of Shenmai Injection on myocardial injury and hemodynamics in patients with post-cardiac arrest syndrome.,Methods,2,A retrospective study method was adopted in the study， and the patients were divided into a treatment group and a control group according to whether Shenmai Injection was used during the course of the disease. On the basis of conventional treatment， the treatment group received 100 mL of Shenmai Injection intravenously twice a day， and the surviving patients persistently received it for 7 days. The control group received conventional treatment. Survivors continued to receive it for 7 days. The changes in the mean arterial pressure （MAP）， lactic acid （Lac）， urine output， left ventricular end-diastolic diameter （LVDD）， left ventricular ejection fraction （LVEF）， brain natriuretic peptide （BNP）， high-sensitivity troponin I （hscTnI）， creatine kinase （CK）， creatine kinase isozyme-MB （CK-MB）， aspartate aminotransferase （AST）， myoglobin （MYO）， and lactate dehydrogenase （LDH） were compared between the two groups before and after treatment. The APACHE II scores， SOFA scores， and 14-day survivals of the two groups of patients were compared between the two groups.,Results,2,The APACHE II scores and SOFA scores of patients in the treatment group after treatment were lower than those before treatment， and the differences were statistically significant （,P,<,0.01）； The LVDD and LVEF of the treatment group were improved compared with those before treatment， and the differences were statistically significant （,P,<,0.05）； The LVEFs of treatment group were higher than those of the control group， and the differences were statistically significant （,P,<,0.05）. Compared with that before treatment， MAPs of patients in the two groups increased significantly and Lacs decreased significantly， and the differences were statistically significant （,P,<,0.05）. The urine outputs of the treatment group increased significantly， and the differences were statistically significant （,P,<,0.01）； after treatment， the MAP and urine output levels of the treatment group were significantly higher than those of the control group， and the differences were statistically significant （,P,<,0.01）. The hscTnI levels of the treatment group were significantly lower than those before treatment， and the differences were statistically significant （,P,<,0.01）. The CK， CK-MB， LDH， AST， and MYO levels of the treatment group decreased more significantly compared with those before treatment and were significantly lower than those of the control group， and the differences were statistically significant （,P,<,0.05， ,P,<,0.01）. The CK levels of the patients in the control group decreased compared with those before treatment， and the differences were statistically significant （,P,<,0.05）. The doses of DA and NE received by patients in the treatment group were both reduced compared with those before treatment and were lower than those of the control group， and the differences were statistically significant （,P,<,0.05）.,Conclusion,2,Shenmai Injection has a positive impact on the prognosis of patients with post-cardiac arrest syndrome， which can maintain hemodynamic stability， reduce myocardial damage， and improve patient prognosis.