Objective,2,To observe the clinical effect of Jianpi Yiqi Huoxue Decoction（invigorating spleen qi and activating blood）combined with alendronate sodium on diabetes mellitus complicated with osteoporosis（DOP）.,Methods,2,A total of 106 DOP patients admitted to the Department of Endocrinology and Diabetes in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from June 2021 to June 2022 were selected and divided into 2 groups according to random number table method. The control group was treated with alendronate sodium tablets. On this basis， the observation group was treated with Jianpi Yiqi Huoxui Decoction. The clinical effect of 2 groups was observed after 6 months of treatment，including Glucose metabolism indexes ［fasting blood glucose（FPG）， HbA,1,c，fasting insulin（FINS）， insulin resistance index（HOMA-IR）］， bone density， TCM syndrome score， hemorheology indexes ［plasma viscosity（PV）， whole blood high tangential viscosity（HBV）， whole blood low tangential viscosity（LBV）， red blood cell aggregation index（EAI）］ of the two groups， serum biochemical indexes of bone metabolism， such as alkaline phosphatase（ALP）， type I procollagen N-terminal peptide（P1NP）， type I collagen cross-linked C-terminal peptide β-degradation product（β-CTX）， insulin-like growth factor 1（IGF-1）and Chemerin levels were were compared before and after treatment. The adverse reactions of the 2 groups were analyzed.,Results,2,The total effective rate of observation group（88.68%）was higher than that of control group（73.58%）（,P,<,0.05）. After treatment， serum levels of FPG， HbA,1,c， FINS and HOMA-IR in 2 groups were lower than that before treatment（,P,<,0.05）. Serum FINS level and HOMA-IR in observation group were lower than those in control group（,P,<,0.05）. Bone mineral density （BMD） from L1 to L4 in both groups was increased compared with that before treatment（,P,<,0.05）， and TCM syndrome score was decreased compared with that before treatment（,P,<,0.05） and The difference was statistically significant（,P,<,0.05）. After the treatment，bone mineral density of femoral neck and total hip in the observation group was higher than that before treatment（,P,<,0.05）， but there was no statistical significance in BMD of femoral neck and hip before and after treatment in the control group（,P,>,0.05）. PV， HBV， LBV and EAI in the 2 groups were lower than before treatment（,P,<,0.05）， and PV， HBV， LBV and EAI in the observation group were lower than those in the control group（,P,<,0.05）. Serum ALP， P1NP and β-CTX levels in 2 groups were lower than those before treatment（,P,<,0.05）， and serum ALP， P1NP and β-CTX levels in observation group were lower than those in control group（,P,<,0.05）. The serum IGF-1 level in 2 groups was higher than before treatment（,P,<,0.05）， and the serum Chemerin level was lower than before treatment（,P,<,0.05）. The serum IGF-1 level in observation group was higher than that in control group（,P,<,0.05）， and the serum Chemerin level was lower than that in control group（,P,<,0.05）. In control group， nausea and headache occurred in 1 case each. Nausea occurred in 2 cases and abdominal pain occurred in 1 case in the observation group. There was no significant difference in the incidence of adverse reactions between the two groups（,P,>,0.05）.,Conclusion,2,The overall curative effect of Jianpi Yiqi Huoxue Decoction combined with alendronate sodium in the treatment of DOP is exact， and its effect may be related to the effective improvement of insulin resistance， correction of hemorheological abnormalities and regulation of serum biochemical indexes of bone metabolism， IGF-1 and Chemerin levels of the integrated traditional Chinese and western medicine program.