Objective

2

To evaluate the clinical effect of Xiefei Lishui Mixture in the treatment of chronic heart failure of qi and blood deficiency

blood stagnation and yang deficiency and water overflowing.

Methods

2

99 patients

who were admitted to the Cardiology Ward

Beijing Hospital of Traditional Chinese Medicine affiliated to the Capital Medical University and the Cardiology Ward of Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from January 2020 to June 2022

were divided into control group（50） and observation group（49） by the random number method. The control group was routinely treated with western medicine according to the guidelines combined with oral Chinese medicine placebo

100 mL each time

twice a day after breakfast and dinner;and the observation group was routinely treated with western medicine according to the guidelines combined with hospital preparations of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University number 4， 100 mL each time

twice a day with warm temperature.and the course of both groups was 6 weeks. Serum Serum n-terminal pro-brain natriuretic peptide （NT-proBNP） levels and cardiac function before and after treatment［Cardiac output （Cardiac output，CO），left ventricular ejection fraction （Left Ventricular Eject Fraction， LVEF）， stroke output （Stroke volume， SV）， left ventricular end-diastolic volume （Left ventricular end diastolic volume，LVEDV）， Left ventricular end-systolic volume （left ventricular end-systolic volume，LVESV）， Ratio of peak flow rate （E/A）］， frequency of re-hospitalization， adverse events and efficacy were compared between the two groups before and after the treatment.

Results

2

After 2 and 6 weeks of treatment

the serum NT-proBNP levels in both groups were lower than before treatment (

P

<

0.05)

and the observation group was lower than the control group (

P

<

0.05). After 2 and 6 weeks of treatment

there were significant differences in LVEDV

LVEV

LVEF

E/A and SV between the observation group and the control group (

P

<

0.05). After 6 weeks of treatment

the CO in the observation group was lower than that in the control group

and the difference was statistically significant (

P

<

0.05). The total effective rate of the observation group was higher than that of the control group (

P

<

0.05).Six months after treatment through follow-up

two patients (4.3%) in the observation group were hospitalized again

which was less than that in the control group (8 cases (17.0%))

and the difference was statistically significant (

P

<

0.05). There were 1 and 2 cases of ventricular arrhythmia and 4 and 6 cases of hypotensi

on in the observation group and the control group

respectively

with no statistical significance (

P

>

0.05). There were no drug-induced sudden death

abnormal urine and stool routine

drug-induced liver and kidney damage and abnormal glucose in both groups.

Conclusion

2

Conventional treatment of western medicine combined with Xiefei Lishui Mixture no. 4 could reduce the serum NT-proBNP in patients with qi deficiency，blood stasis with Yang deficiency and water overflowing in chronic heart failure， improve cardiac function

reduce the frequency of hospitalization with better effect than the simple routine treatment of western medicine

and there is no increase in adverse events.