1.中国中医科学院广安门医院心血管科,北京 100053
2.北京中医药大学研究生院,北京 100029
李赵陵,女,33岁,硕士,主治医师。研究方向:中西医结合心血管疾病防治和研究。
李军,E-mail:gamyylj@163.com
纸质出版日期:2024-04-25,
收稿日期:2023-09-13,
扫 描 看 全 文
李赵陵,白栋汉,谭雨晴,等.益气活血类中药通过PI3K/Akt信号通路防治心肌梗死的研究进展[J].北京中医药,2024,43(4):429-433.
LI Zhaoling,BAI Donghan,TAN Yuqing,et al.Advances in research on prevention and treatment of myocardial infarction through PI3K/Akt signaling pathway with Chinese herbal medicines for nourishing Qi and activating blood[J]. Beijing Journal of Traditional Chinese Medicine,2024,43(04):429-433.
李赵陵,白栋汉,谭雨晴,等.益气活血类中药通过PI3K/Akt信号通路防治心肌梗死的研究进展[J].北京中医药,2024,43(4):429-433. DOI: 10.16025/j.1674-1307.2024.04.023.
LI Zhaoling,BAI Donghan,TAN Yuqing,et al.Advances in research on prevention and treatment of myocardial infarction through PI3K/Akt signaling pathway with Chinese herbal medicines for nourishing Qi and activating blood[J]. Beijing Journal of Traditional Chinese Medicine,2024,43(04):429-433. DOI: 10.16025/j.1674-1307.2024.04.023.
PI3K/Akt信号通路作为调控细胞增殖与凋亡的经典信号通路之一,对促进心肌梗死后心肌组织修复及侧支循环的形成具有重要作用。益气活血类药物被广泛应用于心肌梗死患者的治疗,疗效确切。既往研究表明,益气活血类药物的药理作用与PI3K/Akt信号通路具有显著关联,相关研究丰富了中医防治心血管疾病的科学内涵。
PI3K/Akt信号通路心肌梗死益气活血中医药治疗
HEIDENREICH PA, BOZKURT B, AGUILAR D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: executive summary:a report of the American college of cardiology/American Heart Association Joint Committee on clinical practice guidelines[J]. Circulation,2022,145(18):876-894.
胡盛寿, 王增武. 《中国心血管健康与疾病报告2022》概述[J].中国心血管病研究,2023,21(7):577-600.
MARTYNIAK A,TOMASIK PJ. A new perspective on the renin-angiotensin system[J]. Diagnostics (Basel),2022,13(1):123-128.
ONG SB,HERNÁNDEZ-RESÉNDIZ S,CRESPO-AVILAN GE,et al. Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities[J]. Pharmacol Ther,2018,186:73-87.
TILEA I, VARGA A, SERBAN RC. Past, present, and future of blood biomarkers for the diagnosis of acute myocardial infarction-promises and challenges[J]. Diagnostics (Basel),2021,11(5):23-34.
GHAFOURI-FARD S, KHANBABAPOUR SASI A, HUSSEN BM, et al. Interplay between PI3K/AKT pathway and heart disorders[J]. Mol Biol Rep,2022,49(10):9767-9781.
SAMAKOVA A, GAZOVA A, SABOVA N, et al. The PI3k/Akt pathway is associated with angiogenesis, oxidative stress and survival of mesenchymal stem cells in pathophysiologic condition in ischemia[J]. Physiol Res,2019,68(Suppl 2):131-138.
QIN W, CAO L, MASSEY IY. Role of PI3K/Akt signaling pathway in cardiac fibrosis[J]. Mol Cell Biochem, 2021,476(11):4045-4059.
FRUMAN DA, CHIU H, HOPKINS BD, et al. The PI3K pathway in human disease[J]. Cell,2017,170(4):605-635.
YANG J,NIE J,MA X,et al. Targeting PI3K in cancer:mechanisms and advances in clinical trials[J]. Mol Cancer,2019,18(1):26.
HERS I, VINCENT EE, TAVARÉ JM. Akt signalling in health and disease[J]. Cell Signal,2011,23(10):1515-1527.
HUA H, ZHANG H, CHEN J, et al. Targeting Akt in cancer for precision therapy[J]. J Hematol Oncol,2021,14(1):128.
XIA P, XU XY. PI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical application[J]. Am J Cancer Res,2015,5(5):1602-1609.
POMPURA SL,DOMINGUEZ-VILLAR M. The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function[J]. J Leukoc Biol,2018,79(6):1019-1031.
NATHAN N, KEPPLER-NOREUIL KM, BIESECKER LG, et al. Mosaic disorders of the PI3K/PTEN/AKT/TSC/mTORC1 signaling pathway[J]. Dermatol Clin, 2017,35(1):51-60.
ZHANG M, ZHANG X. The role of PI3K/AKT/FOXO signaling in psoriasis[J]. Arch Dermatol Res,2019,311(2):83-91.
AIMO A, CASTIGLIONE V, BORRELLI C, et al. Oxidative stress and inflammation in the evolution of heart failure: from pathophysiology to therapeutic strategies[J]. Eur J Prev Cardiol,2020,27(5):494-510.
SONGBO M, LANG H, XINYONG C, et al. Oxidative stress injury in doxorubicin-induced cardiotoxicity[J]. Toxicol Lett,2019,307:41-48.
JAIN AK, MEHRA NK, SWARNAKAR NK. Role of antioxidants for the treatment of cardiovascular diseases: challenges and opportunities[J]. Curr Pharm Des,2015,21(30):4441-4455.
ORNELLAS FM, ORNELLAS DS, MARTINI SV, et al.Bone marrow-derived mononuclear cell therapy accelerates renal ischemia-reperfusion injury recovery by modulating inflammatory, antioxidant and apoptotic related molecules[J]. Cell Physiol Biochem,2017,41(5):1736-1752.
LIAO L, GONG L, ZHOU M, et al. Leonurine ameliorates oxidative stress and insufficient angiogenesis by regulating the PI3K/Akt-eNOS signaling pathway in H2O2-induced HUVECs[J]. Oxid Med Cell Longev,2021:9919466.
KU HC, LEE SY, YANG KC, et al. Modification of caffeic acid with pyrrolidine enhances antioxidant ability by activating AKT/HO-1 pathway in heart[J]. PLoS One,2016,11(2):e0148545.
ZHANG Q, LIU J, DUAN H, et al. Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress[J]. J Adv Res,2021,34:43-63.
刘雪岩, 李成花, 杨萍.炎症反应在心梗后心衰发病过程中的作用研究进展[J]. 分子影像学杂志,2017,40(1):81-84.
FRANGOGIANNIS NG.The inflammatory response in myocardial injury, repair, and remodelling[J]. Nat Rev Cardiol,2014,11(5):255-265.
朱志扬, 葛然, 杨露露. 人参皂苷Rb1通过抑制PI3K/AKT信号通路保护脂多糖诱导的心肌细胞炎症反应[J]. 中国循证心血管医学杂志,2018,10(7):823-826.
LI D, GUO YY, CEN XF, et al. Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways[J]. Acta Pharmacol Sin, 2022,43(8):1989-2002.
陈浥尘, 陈广洁, 陈红. M1/M2型巨噬细胞与心血管疾病关系的研究进展[J].现代免疫学,2015,35(6):507-510.
VERGADI E, IERONYMAKI E, LYRONI K, et al. Akt signaling pathway in macrophage activation and M1/M2 polarization[J]. J Immunol, 2017,198(3):1006-1014.
YIN J, HU L, HAN X, et al. MiR-18a-5p aggravates homocysteine-induced myocardial injury via autophagy[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023,48(1):24-33.
BEROSKE L,VAN DEN WYNGAERT T,STROOBANTS S, et al. Molecular imaging of apoptosis: the case of caspase-3 radiotracers[J]. Int J Mol Sci,2021,22(8):88-99.
PAHLAVANI HA. Exercise-induced signaling pathways to counteracting cardiac apoptotic processes[J]. Front Cell Dev Biol,2022,10:950927.
CHEN X, ZHANG H, FENG M, et al. A novel peptide HSP-17 ameliorates oxidative stress injury and apoptosis in H9c2 cardiomyocytes by activating the PI3K/Akt pathway[J]. Ann Transl Med, 2022,10(24):1357.
MCLOUGHLIN NM, MUELLER C, GROSSMANN TN. The therapeutic potential of PTEN modulation: targeting strategies from gene to protein[J]. Cell Chem Biol, 2018,25(1):19-29.
WEN Z, MAI Z, ZHU X, et al. Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway[J]. Stem Cell Res Ther, 2020,11(1):36.
LU JM, ZHANG ZZ, MA X, et al. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy[J]. Exp Eye Res, 2020,190:107886.
CHENG Y, JIANG S, HU R, et al. Potential mechanism for endothelial progenitor cell therapy in acute myocardial infarction: Activation of VEGF- PI3K/Akte-NOS pathway[J]. Ann Clin Lab Sci, 2013,43(4):395-401.
耿军辉, 张丽军, 王亚丽,等. PI3K/Akt信号通路与肿瘤血管新生的研究进展[J]. 现代肿瘤医学,2018,26(9):1462-1466.
程嵩奕.黄芪甲苷调控PTEN/PI3K/Akt信号通路介导心肌梗死后血管新生与心肌保护的实验研究[D].南京:南京中医药大学,2018.
JING R, ZHONG QQ, LONG TY, et al. Downregulated miRNA-26a-5p induces the apoptosis of endothelial cells in coronary heart disease by inhibiting PI3K/AKT pathway[J]. Eur Rev Med Pharmacol Sci, 2019,23(11):4940-4947.
李军, 张振鹏, 熊兴江,等.稳心汤治疗不稳定性心绞痛的随机对照研究[J].中国实验方剂学杂志,2016,22(4):154-158.
张丞波, 张苏洁, 杨月东,等. 益气活血方对急性ST段抬高型心肌梗死后心力衰竭患者心肌纤维化的影响[J]. 南京中医药大学学报,2023,39(2):111-117.
何贵新, 肖婷, 秦伟彬,等. 基于PI3K/AKT信号通路探讨芪参益气滴丸改善心肌缺血再灌注损伤的实验研究[J]. 北京中医药大学学报,2020,43(9):762-768.
ZHANG J, CUI Q, ZHAO Y, et al. Mechanism of angiogenesis promotion with Shexiang Baoxin Pills by regulating function and signaling pathway of endothelial cells through macrophages[J]. Atherosclerosis, 2020,292:99-111.
ZHANG B, MA Q, MA FZ, et al. Astragaloside Ⅳ's therapeutic effect on myocardial infarction via affecting autophagy and the mechanism study[J]. Sichuan Da Xue Xue Bao Yi Xue Ban, 2021,52(2):222-228.
LIU H, LIU W, QIU H, et al. Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway[J]. Naunyn Schmiedebergs Arch Pharmacol, 2020,393(8):1527-1539.
CHEN X, XIE Q, ZHU Y, et al. Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways[J]. Eur J Pharmacol, 2021,911:174495.
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构