白头翁汤治疗溃疡性结肠炎的信号通路机制分析
Mechanism of Baitouweng Decoction in alleviating ulcerative colitis via signaling pathways
- 北京中医药 2024年43卷第9期 页码：981-985
- 作者机构：
中国中医科学院望京医院脾胃病科，北京 100102
- 作者简介：
孙巍琪，女，25岁，硕士研究生。研究方向：中医防治消化系统疾病。
魏玮，E-mail：sxxtyy@sina.com
- 基金信息：国家重大疑难病中西医协作试点项目(国中医药办医政发〔2018〕3号);中医药防治消化道癌前疾病传承与创新团队项目(ZYYCXTD-C-202210);中国中医科学院科技创新工程项目(CI2021A03319)
DOI：10.16025/j.1674-1307.2024.09.004
中图分类号：纸质出版日期：2024-09-25，
收稿日期：2024-06-20，
- 稿件说明：
移动端阅览
孙巍琪，张旖晴，魏玮.白头翁汤治疗溃疡性结肠炎的信号通路机制分析［J］.北京中医药，2024，43（9）：981-985.
SUN Weiqi,ZHANG Yiqing,WEI Wei.Mechanism of Baitouweng Decoction in alleviating ulcerative colitis via signaling pathways[J]. Beijing Journal of Traditional Chinese Medicine,2024,43(09):981-985.
孙巍琪，张旖晴，魏玮.白头翁汤治疗溃疡性结肠炎的信号通路机制分析［J］.北京中医药，2024，43（9）：981-985. DOI： 10.16025/j.1674-1307.2024.09.004.
SUN Weiqi,ZHANG Yiqing,WEI Wei.Mechanism of Baitouweng Decoction in alleviating ulcerative colitis via signaling pathways[J]. Beijing Journal of Traditional Chinese Medicine,2024,43(09):981-985. DOI： 10.16025/j.1674-1307.2024.09.004.
摘要
溃疡性结肠炎（UC）是一种反复发作的炎症性肠病。目前研究认为，其发病与肠道上皮屏障缺陷、肠道菌群失调、免疫应答失调及遗传等因素密切相关。白头翁汤治疗UC具有一定的疗效。白头翁汤及其加减方可通过多种信号通路减少促炎细胞因子的表达，增加机体抗炎因子，促进肠上皮细胞增殖以加速肠上皮修复，保护肠道黏液屏障，减轻肠道炎症反应，从而减少肠上皮细胞异常增殖，避免“炎-癌”的发生。
Abstract
Ulcerative colitis （UC） is a recurrent inflammatory bowel disease. Current research suggests that its pathogenesis is closely related to factors such as intestinal epithelial barrier defects， gut microbiota dysbiosis， immune response disorders， and genetics. Baitouweng Decoction has shown certain efficacy in treating UC. Baitouweng Decoction and its modified formulas can reduce the expression of pro-inflammatory cytokines through multiple signaling pathways， increase anti-inflammatory factors， promote the proliferation of intestinal epithelial cells to accelerate epithelial repair， protect the intestinal mucosal barrier， and alleviate intestinal inflammation. In this way， they reduce abnormal proliferation of intestinal epithelial cells and prevent the occurrence of inflammation-induced cancer.
关键词
溃疡性结肠炎白头翁汤IL-6/JAK/STAT3信号通路mTORC1-STAT3-COX-2信号通路Notch信号通路
Keywords
Ulcerative colitisBaitouweng Decoctionthe IL-6/JAK2/STAT3 pathway， the mTORC1-STAT3-COX-2 pathway， the Notch pathway
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