Objective

2

To explore the effect of Shenyuan Yiqi Huoxue Capsules（SYD）on myocardial injury and coronary microcirculation in patients with unstable angina（UA）following percutaneous coronary intervention（PCI）.

Methods

2

A total of 68 patients with coronary heart disease（CHD）and UA who were treated in the Department of Vasculocardiology at Beijing Hospital of Traditional Chinese Medicine，Capital Medical University from June 2019 to June 2023 were enrolled and randomly divided into an observation group and a control group according to a random number table，with 34 patients in each group.The observation group received SYD orally in addition to standardized treatment，while the control group received placebo（PBO）orally in addition to standardized treatment.Both groups underwent PCI.The myocardial injury markers， including creatine kinase-MB（CK-MB），CK-MB peak values，coronary microcirculation index（IMR），and the change rate of IMR（△IMR）in both groups，were compared before and after treatment，along with safety evaluations.The correlation between CK-MB peak values and △IMR was analyzed using Spearman's correlation method.

Results

2

Twenty-four hours after surgery，the CK-MB levels in both groups were higher than those before surgery（

P

<

0.05），and

the observation group had lower CK-MB levels than the control group（

P

<

0.05）.At 72 hours post-surgery，the CK-MB levels in both groups showed no significant difference compared with pre-treatment values（

P

>

0.05）.The CK-MB levels in the observation group were lower than in the control group，but the difference was not statistically significant（

P

>

0.05）.The peak CK-MB value in the observation group was lower than in the control group（

P

<

0.05）.After surgery，the IMR levels in both groups were higher than those before surgery（

P

<

0.05），but the difference between the two groups was not statistically significant（

P

>

0.05）.The △IMR value in the observation group was lower than in the control group（

P

<

0.05）.There was no significant correlation between CK-MB peak value and △IMR in the control group（

r

=-0.158 5，

P

>

0.05），while in the observation group，a positive correlation was found between CK-MB peak value and △IMR（

r

=0.339 2，

P

<

0.05）.In the observation group，one patient had poor lipid control and developed elevated alanine aminotransferase（ALT）after doubling the dose of atorvastatin，which returned to normal after stopping the medication.No abnormalities in liver or kidney function，routine blood/urine tests，or coagulation indicators were observed in the remaining patients.No drug-related dermatitis，bleeding，or other adverse reactions were observed in either group.

Conclusion

2

SYD can improve myocardial injury and coronary microcirculation in patients with UA after PCI，with high safety.