
浏览全部资源
扫码关注微信
1.浙江中医药大学附属第一医院肾病科,杭州 310003
2.温州医科大学附属温岭医院泌尿外科,温岭 317500
3.北京中医药大学东直门医院男科,北京 100700
4.云南中医药大学第一附属医院男科,昆明 650021
5.南通大学附属医院泌尿外科,南通 226001
马健雄,男,34岁,博士,助理研究员。研究方向:中医药防治男科疾病。
赵凡,E-mail: zhaofan@ntu.edu.cn
纸质出版日期:2025-01-25,
收稿日期:2024-06-20,
移动端阅览
马健雄, 叶妙勇, 李海松, 等. 从络病理论探讨糖尿病性勃起功能障碍的病机及治法[J]. 北京中医药, 2025,44(1):23-27.
MA JIANXIONG, YE MIAOYONG, LI HAISONG, et al. Pathogenesis and therapeutic methods of diabetic erectile dysfunction based on collateral disease theory. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 23-27.
马健雄, 叶妙勇, 李海松, 等. 从络病理论探讨糖尿病性勃起功能障碍的病机及治法[J]. 北京中医药, 2025,44(1):23-27. DOI: 10.16025/j.1674-1307.2025.01.005.
MA JIANXIONG, YE MIAOYONG, LI HAISONG, et al. Pathogenesis and therapeutic methods of diabetic erectile dysfunction based on collateral disease theory. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 23-27. DOI: 10.16025/j.1674-1307.2025.01.005.
糖尿病性勃起功能障碍(ED)是糖尿病常见并发症之一,属难治性勃起功能障碍(RED),临床治疗策略尚需探讨。基于“络病理论”并结合阴茎海绵体特有解剖结构,提出糖尿病性ED等RED应归属为“阴茎络病”的观点,继而从病位、病因、病理三位一体探讨糖尿病性ED病机及治法。“阴茎络脉”为糖尿病性ED之微观病位,“内热伏体”状态是糖尿病性ED发生发展的特异性病因,阴茎络脉微癥积则是糖尿病性ED的关键病理变化,治疗重在益气活血、通络消癥,兼除伏热之邪。
Diabetic erectile dysfunction (ED) is one of the common complications of diabetes and is classified as refractory erectile dysfunction (RED), for which clinical treatment strategies still need to be explored. Based on the "collateral disease theory" and the unique anatomical structure of the penile corpus cavernosum, it was proposed that RED, including diabetic ED, should be classified as "penis collateral disease". From this perspective, the pathogenesis and treatment methods of diabetic ED were discussed through a trinity approach, considering disease location, etiology, and pathology. The "penile collateral vessels" represent the micro-location of diabetic ED. The "internal heat" condition is a specific cause of the onset and progression of diabetic ED, and micro-lumps in the penile collateral vessels are the key pathological changes in diabetic ED. Treatment should focus on replenishing qi and activating blood, dredging collaterals, dispelling micro-lumps, and clearing the internal heat pathogen.
糖尿病性勃起功能障碍难治性勃起功能障碍阴茎络病内热伏体微癥积
Diabetic erectile dysfunctionrefractory erectile dysfunctionpenis collateral diseaseinternal heatmicro-lumps
《糖尿病合并男性性功能障碍多学科中国专家共识》编写专家委员会. 糖尿病合并男性性功能障碍多学科中国专家共识[J]. 中国男科学杂志,2022,36(1):3-33.
赵凡,李海松,张春和,等.难治性勃起功能障碍中西医结合防治策略述评[J].中华中医药杂志,2023,38(9):4013-4021.
王世伟,徐宁,史翠娟.糖尿病勃起功能障碍的中医诊治概况[J].江西中医药,2016,47(12):79-80.
李宪锐,张耀圣,王景尚,等.糖尿病性勃起功能障碍中西医机理研究及治疗进展[J].中国性科学,2020,29(1):111-115.
吴以岭,袁国强,贾振华,等.脉络学说的学术地位及其应用价值[J].中医杂志,2012,53(1):3-7.
李红蓉,吴以岭.络病研究的传承与创新[J].南京中医药大学学报,2022,38(12):1075-1085.
仝小林.糖络杂病论[M].3版.北京:科学出版社,2020:6.
高亚斌,王耀献,郭敬,等.“以热为本,以期为纲”论治晚期糖尿病肾病[J].中华中医药杂志,2020,35(2):714-716.
李海松,马健雄,王彬,等.阴茎中风探讨[J].中医杂志,2015,56(23):2064-2066.
吴以岭.络病学概要[J].疑难病杂志,2004,3(1):37-39.
SEGURO A,GLINA S.Prevalence,risk factors,and erectile dysfunction associated with Peyronie's Disease among men seeking urological care[J].Sex Med,2020,8(2):230-236.
GIANAZZA S,BELLADELLI F,LENI R,et al. Peyronie's Disease development and management in diabetic men[J]. Andrology, 2023,11(2):372-378.
KIM J, DRURY R, MORENAS R, et al. Pathophysiology and grayscale ultrasonography of penile corporal fibrosis[J]. Sex Med Rev, 2022,10(1):99-107.
LUAN Y,CUI K,TANG Z,et al. Human tissue kallikrein 1 improves erectile dysfunction of streptozotocin-induced diabetic rats by inhibition of excessive oxidative stress and activation of the PI3K/AKT/eNOS pathway[J]. Oxid Med Cell Longev, 2020:6834236.
JEONG HC, JEON SH, QUN ZG, et al. Effects of next-generation low-energy extracorporeal shockwave therapy on erectile dysfunction in an animal model of diabetes[J]. World J Mens Health, 2017,35(3):186-195.
赵凡,叶妙勇,赵剑锋,等.阴茎海绵体平滑肌细胞表型转化和勃起功能障碍的相关研究进展[J].中华男科学杂志,2018,24(10):927-932.
KWON MH, RHO BY, CHOI MJ, et al. BMP2 restores erectile dysfunction through neurovascular regeneration and fibrosis reduction in diabetic mice[J]. Andrology, 2024,12(2):447-458.
HICKS CW, WANG D, WINDHAM BG, et al. Association of peripheral neuropathy with erectile dysfunction in US Men[J]. Am J Med, 2021,134(2):282-284.
刘媛媛,傅强,刘轶凡,等.微型癥瘕理论及扶正消癥法的应用浅析[J].北京中医药,2022,41(7):754-757.
马凰富,马健雄,赵冰,等.李海松教授“阴茎中风”学说在治疗勃起功能障碍中的应用[J].环球中医药,2016,9(5):594-596.
杨瑞耕,蒋里,苏冠旬,等.糖尿病肾病的“络虚-瘕聚-生风”病机探讨[J].北京中医药,2024,43(6):703-706.
李霄.活血通络起痿汤对糖尿病勃起功能障碍的临床与实验研究[D].北京:北京中医药大学,2019.
孙松,王继升,徐少强,等.活血通络起痿汤联合小剂量他达拉非治疗血瘀肾虚型糖尿病勃起功能障碍临床观察[J].时珍国医国药,2021,32(1):124-126.
王保群,杨立波,杨洪乐,等.通心络胶囊治疗2型糖尿病勃起功能障碍的研究[J].中药药理与临床,2014,30(2):171-173.
商建伟.基于PI3K/Akt及RhoA/Rho信号通路探讨填精通络法对DIED大鼠的作用机制及配伍规律[D].北京:北京中医药大学,2019.
叶妙勇,赵凡,王军卫,等.补阳还五汤对糖尿病性勃起功能障碍大鼠阴茎海绵体纤维化及RhoA、ROCK2蛋白表达的影响[J].中国中西医结合杂志,2022,42(11):1369-1375.
杨若聪.水蛭素改善糖尿病型ED的网络药理学和在体药效评价研究[D].北京:北京中医药大学,2020.
MA JX, WANG B, DING CF, et al. Couplet medicines of leech and centipede granules improve erectile dysfunction via inactivation of the CaSR/PLC/PKC signaling in streptozotocin-induced diabetic rats[J]. Biosci Rep, 2020,40(2):20193845.
MA JX,WANG B,LI HS,et al.Uncovering the mechanisms of leech and centipede granules in the treatment of diabetes mellitus-induced erectile dysfunction utilising network pharmacology[J].J Ethnopharmacol, 2021,265:113358.
WANG JS,FENG JL,LI X,et al.Effect of leech-centipede medicine on improving erectile function in diabetes-induced erectile dysfunction rats via PDE5 signalling pathway-related molecules[J].Pharm Biol,2021,59(1):167-174.
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备 11010102006710号