Objective

2

To observe the clinical efficacy of Wumei Pills decoction in the treatment of sepsis complicated with diarrhea and gastrointestinal dysfunction.

Method

2

Patients with sepsis complicated by diarrhea and gastrointestinal dysfunction who visited the Emergency Department of Beijing Hospital of Traditional Chinese Medicine， Capital Medical University from April 2016 to March 2022 were enrolled and randomly divided into an observation group and a control group using a random number table. Both groups received conventional treatment， with the observation group additionally receiving Wumei Pills decoction orally， via nasogastric tube， or rectal drip. The treatment duration was 7 days for both groups. The mortality rate， diarrhea efficacy， safety， and changes in gastrointestinal dysfunction scores， sequential organ failure assessment （SOFA） scores， and acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ） scores were observed before and after treatment.

Result

2

In the observation group， 5 deaths （16.13%） occurred， while in the control group， 9 deaths （29.03%） occurred. There was no statistically significant difference in mortality between the two groups （

P

>

0.05）， and the relative risk of death was 0.85 （95% CI： 0.644–1.112）. The overall effective rate in the observation group was higher than that in the control group （

P

<

0.05）. Compared with the results before treatment， both groups showed a decrease in gastrointestinal dysfunction scores， SOFA scores， and APACHE Ⅱ scores after treatment （

P

<

0.05）. Additionally， the observation group had significantly lower gastrointestinal dysfunction scores， SOFA scores， and APACHE Ⅱ scores than the control group after treatment （

P

<

0.05）. No drug-related adverse reactions occurred in either group， and there were no significant changes in blood routine or liver and kidney function in either group.

Conclusion

2

Wumei Pills decoction has a significant gastrointestinal protective effect on patients with sepsis complicated by diarrhea and gastrointestinal dysfunction， and it also alleviates the overall severity of the patient's condition.