益气活血、化痰通络法治疗煤工尘肺缓解期患者的临床研究

白晓旭; 张红; 王勇奇; 苏连华; 李伟; 武艳; 王惠欣; 汪刚; 余新波

doi:10.16025/j.1674-1307.2025.01.012

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益气活血、化痰通络法治疗煤工尘肺缓解期患者的临床研究

临床研究 | 更新时间：2025-01-24

- 益气活血、化痰通络法治疗煤工尘肺缓解期患者的临床研究
- A clinical study of treating coal miners' pneumoconiosis in remission with Qi-invigorating, blood-activating, phlegm-resolving, and collateral-dredging methods
- 北京中医药 2025年44卷第1期页码：57-60
- 作者机构：
  
  1.北京中医药大学房山医院肺病科，北京 102400
  2.北京中医药大学房山医院内科，北京 102400
- 作者简介：
  
  白晓旭，女，40岁，博士，主治医师。研究方向：中西医结合治疗肺系疾病。
- 基金信息：
  
  北京市中医药科技发展资金项目(JJ-2020-44);首都卫生发展科研专项(首发2022-2-7073)
- DOI：10.16025/j.1674-1307.2025.01.012
  中图分类号：
- 纸质出版日期：2025-01-25，
  
  收稿日期：2024-05-09，
- 稿件说明：
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白晓旭, 张红, 王勇奇, 等. 益气活血、化痰通络法治疗煤工尘肺缓解期患者的临床研究[J]. 北京中医药, 2025,44(1):57-60.

BAI XIAOXU, ZHANG HONG, WANG YONGQI, et al. A clinical study of treating coal miners' pneumoconiosis in remission with Qi-invigorating, blood-activating, phlegm-resolving, and collateral-dredging methods. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 57-60.
白晓旭, 张红, 王勇奇, 等. 益气活血、化痰通络法治疗煤工尘肺缓解期患者的临床研究[J]. 北京中医药, 2025,44(1):57-60. DOI： 10.16025/j.1674-1307.2025.01.012.

BAI XIAOXU, ZHANG HONG, WANG YONGQI, et al. A clinical study of treating coal miners' pneumoconiosis in remission with Qi-invigorating, blood-activating, phlegm-resolving, and collateral-dredging methods. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 57-60. DOI： 10.16025/j.1674-1307.2025.01.012.

摘要

目的

评价益气活血、化痰通络法治疗对煤工尘肺（CWP）缓解期患者呼吸困难、肺功能、生活质量等指标的改善情况。

方法

选取2020年10月—2022年9月北京中医药大学房山医院就诊的CWP缓解期患者80例，采用随机数字表法分为观察组与对照组。观察组给予西医常规治疗加益气活血、化痰通络颗粒，1剂/d，分早晚2次口服。对照组给予西医常规治疗加安慰剂，1剂/d，分早晚2次口服。2组疗程均4周，随访8周。对比2组呼吸困难疗效及安全性评价，治疗前后肺功能指标［第1秒用力呼气容积（FEV1）、用力肺活量（FVC）及FEV1/FVC］、6分钟步行距离、中医症状积分。

结果

治疗4周后，观察组总有效率86.8%，高于对照组的61.5%（

0.05）。治疗第4周，观察组中医症状积分低于治疗前及对照组（

0.05）；观察组FVC高于治疗前（

0.05）。治疗第4周、随访第4周，观察组6分钟步行距离均长于治疗前（

0.05），第4周2组间差异有统计学意义（

0.05）。在治疗及随访期间，2组患者均未发生不良事件。

结论

益气活血、化痰通络法联合西医治疗可降低CWP缓解期患者的呼吸困难程度，并对中医症状积分、FVC和6分钟步行距离有改善作用。

Abstract

Objective

To evaluate the improvement of dyspnea， pulmonary function， and quality of life indicators in patients with coal workers' pneumoconiosis （CWP） in remission treated with qi-invigorating， blood-activating， phlegm-resolving， and collateral-dredging methods.

Methods

A total of 80 male patients with CWP in remission， who visited Fangshan Hospital of Beijing University of Chinese Medicine from October 2020 to September 2022， were selected and randomly divided into an observation group and a control group using a random number table. The observation group received conventional Western medical treatment combined with qi-invigorating， blood-activating， phlegm-resolving， and collateral-dredging granules， 1 dose per day， divided into two oral administrations （morning and evening）. The control group received conventional Western medical treatment combined with a placebo. Both groups received treatment for 4 weeks， followed by an 8-week follow-up. The efficacy of dyspnea relief， pulmonary function indicators ［forced expiratory volume in 1 second （FEV1）， forced vital capacity （FVC）， and FEV1/FVC］， 6-minute walking distance， traditional Chinese medicine （TCM） symptom scores， and safety were compared between the two groups.

Results

At the 4th week of treatment， the total effective rate in the observation group was higher than that in the control group （

0.05）. The TCM symptom score in the observation group was lower than that before treatment and that in the control group after treatment （

0.05）. Compared with the results before treatment， the FVC in the observation group increased （

0.05）， and at both the 4th week of treatment and the 4th week of follow-up， the 6-minute walking distance was longer （

0.05）. The 6-minute walking distance in the observation group at the 4th week of treatment was greater than in the control group （

0.05）. During both the treatment and follow-up periods， no discomfort or adverse events were reported in either group.

Conclusion

The combination of qi-invigorating， blood-activating， phlegm-resolving， and collateral-dredging methods with Western medical treatment can reduce the degree of dyspnea in patients with CWP in remission and improve TCM symptom scores， FVC， and the 6-minute walking distance

关键词

煤工尘肺缓解期益气活血、化痰通络

Keywords

Coal workers' pneumoconiosisremission periodQi-invigorating， blood-activating， phlegm-resolving， and collateral-dredging

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