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天津中医药大学第一附属医院肾病科 国家中医针灸临床医学研究中心,天津 300193
刘冰,女,24岁,硕士研究生。研究方向:中医、中西医结合治疗肾脏病。
裴明,E-mail: tjtcmpeiming@126.com
收稿日期:2024-11-27,
纸质出版日期:2025-02-25
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刘冰,杨洪涛,彭奕雯,等.基于黏膜免疫浅析针灸在IgA肾病治疗中的作用[J].北京中医药,2025,44(2):128-131.
LIU Bing,YANG Hongtao,PENG Yiwen,et al.Effect of acupuncture and moxibustion in the treatment of IgA nephropathy based on mucosal immunity[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(02):128-131.
刘冰,杨洪涛,彭奕雯,等.基于黏膜免疫浅析针灸在IgA肾病治疗中的作用[J].北京中医药,2025,44(2):128-131. DOI: 10.16025/j.1674-1307.2025.02.003.
LIU Bing,YANG Hongtao,PENG Yiwen,et al.Effect of acupuncture and moxibustion in the treatment of IgA nephropathy based on mucosal immunity[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(02):128-131. DOI: 10.16025/j.1674-1307.2025.02.003.
IgA肾病(IgAN)是全球最常见的原发性肾小球肾炎之一,其病因与发病机制尚未完全明确。黏膜免疫系统的失调及黏膜感染与IgA肾病的发病密切相关,针灸治疗可通过调节机体免疫功能,使阴平阳秘,改善黏膜免疫屏障的功能,从而减少病原体入侵和炎症反应的发生。故本文探讨针灸对黏膜免疫功能的调节作用,为中医治疗IgA肾病提供新的思路与方法。
MCGROGAN A , FRANSSEN CFM , DE VRIES CS . The incidence of primary glomerulonephritis worldwide: a systematic review of the literature [J ] . Nephrol Dial Transplant , 2011 , 26 ( 2 ): 414 - 430 .
STAMELLOU E , SEIKRIT C , TANG SCW , et al . IgA nephropathy [J ] . Nat Rev Dis Primers , 2023 , 9 ( 1 ): 67 .
ZAIDI O , DU F , TANG Z , et al . Review on epidemiology,disease burden, and treatment patterns of IgA nephropathy in select APAC countries [J ] . BMC nephrology , 2024 , 25 ( 1 ): 136 .
BARRATT J , LAFAYETTE RA , ZHANG H , et al . IgA nephropathy:the lectin pathway and implications for targeted therapy [J ] . Kidney Int , 2023 , 104 ( 2 ): 254 - 264 .
MYETTE JR , KANO T , SUZUKI H , et al . A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy [J ] . Kidney International , 2019 , 96 ( 1 ): 104 - 116 .
ROVIN BH , BARRATT J , HEERSPINK HJL , et al . Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial [J ] . Lancet , 2023 , 402 ( 10417 ): 2077 - 2090 .
陈娴 , 吕继成 . IgA肾病靶向新药的研究进展 [J ] . 临床内科杂志 , 2024 , 41 ( 1 ): 13 - 16 .
胡晓平 , 周方威 , 邓颖平 . 雷火灸配合口服雷公藤多苷片治疗IgA肾病的疗效观察 [J ] . 上海针灸杂志 , 2020 , 39 ( 7 ): 818 - 822 .
GESUALDO L , DI LEO V , COPPO R . The mucosal immune system and IgA nephropathy [J ] . Semin Immunopathol , 2021 , 43 ( 5 ): 657 - 668 .
孙谨怡 , 盛梅笑 . 基于黏膜免疫机制的IgA肾病中医认识及治疗进展 [J ] . 浙江中医药大学学报 , 2021 , 45 ( 3 ): 306 - 309,314 .
王金泉 . IgA肾病的遗传易感性和黏膜免疫应答异常 [J ] . 医学研究生学报 , 2016 , 29 ( 2 ): 120 - 125 .
HE JW , ZHOU XJ , LYU JC , et al . Perspectives on how mucosal immune responses,infections and gut microbiome shape IgA nephropathy and future therapies [J ] . Theranostics , 2020 , 10 ( 25 ): 11462 - 11478 .
SUZUKI H , KIRYLUK K , NOVAK J , et al . The pathophysiology of IgA nephropathy [J ] . J Am Soc Nephrol , 2011 , 22 ( 10 ): 1795 - 1803 .
SELVASKANDAN H , BARRATT J , CHEUNG CK . Immunological drivers of IgA nephropathy: exploring the mucosa-kidney link [J ] . Int J Immunogenet , 2022 , 49 ( 1 ): 8 - 21 .
COPPO R . The intestine-renal connection in IgA nephropathy [J ] . Nephrol Dial Transplant , 2015 , 30 ( 3 ): 360 - 366 .
吴柳青 , 于国泳 , 张旭杰 , 等 . 基于黏膜免疫探讨“三焦为相火之用”在IgA肾病治疗中的作用 [J/OL ] . 中医学报 , 2024 : 1 - 9 .[ 2024-10-18 ] . http://kns.cnki.net/kcms/detail/41.1411.R.20241018.0916.004.html http://kns.cnki.net/kcms/detail/41.1411.R.20241018.0916.004.html .
BARRATT J , KRISTENSEN J , PEDERSEN C , et al . Insights on nefecon®, a targeted-release formulation of budesonide and its selective immunomodulatory effects in patients with IgA nephropathy [J ] . Drug Des Devel Ther , 2024 , 18 : 3415 - 3428 .
LAFAYETTE R , KRISTENSEN J , STONE A , et al . Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd):2-year results from a randomised phase 3 trial [J ] . Lancet , 2023 , 402 ( 10405 ): 859 - 870 .
杨嘉心 , 刘璐慜 , 胡俊威 , 等 . 针刺治疗变应性鼻炎的累积效应观察 [J ] . 北京中医药 , 2022 , 41 ( 6 ): 602 - 605 .
齐翎羽 , 周航 , 闫世艳 , 等 . 针灸治疗功能性胃肠病的临床证据与展望 [J ] . 北京中医药 , 2022 , 41 ( 10 ): 1200 - 1202 .
ULLOA L , QUIROZ-GONZALEZ S , TORRES-ROSAS R . Nerve stimulation: immunomodulation and control of inflammation [J ] . Trends Mol Med , 2017 , 23 ( 12 ): 1103 - 1120 .
PABST O , IZCUE A . Secretory IgA: controlling the gut microbiota [J ] . Nat Rev Gastroenterol Hepatol , 2022 , 19 ( 3 ): 149 - 150 .
林卓婷 , 刘肖妮 , 金炳旭 , 等 . 温和灸对脑瘫患者慢性腹泻的肠道菌群调节及疗效观察 [J ] . 上海针灸杂志 , 2019 , 38 ( 10 ): 1122 - 1125 .
唐娅妮 , 崔艺敏 , 何轶帆 , 等 . 艾灸热、光、烟作用机制研究进展 [J ] . 中国中医药信息杂志 , 2022 , 29 ( 11 ): 148 - 151 .
ZHANG X , TAN R , LAM WC , et al . PRISMA extension for moxibustion 2020: recommendations, explanation, and elaboration [J ] . Syst Rev , 2020 , 9 ( 1 ): 247 .
王晓燕 . 隔药饼灸对虚寒胃痛和脾虚泄泻患者免疫功能的影响 [J ] . 中国针灸 , 2004 ( 11 ): 18 - 20 .
孙晖 , 张波 , 钱海华 , 等 . 结直肠癌根治术后温针灸干预对患者免疫功能和肠道菌群的影响 [J ] . 针刺研究 , 2021 , 46 ( 7 ): 592 - 597 .
梁毓恬 , 饶向荣 , 方雅炫 , 等 . 饶向荣辨证治疗IgA肾病的经验 [J ] . 北京中医药 , 2024 , 43 ( 5 ): 502 - 505 .
王欢 , 徐佳美 . 穴位艾灸治疗IgA肾病伴夜尿增多30例效果观察 [J ] . 中国乡村医药 , 2015 , 22 ( 4 ): 50 , 60 .
张倩 , 李同侠 , 石凯峰 , 等 . 基于“腰以下肿,当利小便”针刺治疗肾病综合征难治性水肿1例 [J ] . 中医杂志 , 2024 , 65 ( 6 ): 657 - 660 .
ROLLENSKE T , BURKHALTER S , MUERNER L , et al . Parallelism of intestinal secretory IgA shapes functional microbial fitness [J ] . Nature , 2021 , 598 ( 7882 ): 657 - 661 .
KAU AL , PLANER JD , LIU J , et al . Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy [J ] . Sci Transl Med , 2015 , 7 ( 276 ): 276ra24 .
ZHU MF , XING X , LEI S , et al . Electroacupuncture at bilateral zusanli points(st36)protects intestinal mucosal immune barrier in sepsis [J ] . Evid Based Complement Alternat Med , 2015 : 639412 .
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