基于“郁毒致虚”理论探讨参百灵颗粒治疗乳腺癌癌因性疲乏的机制

高晓宇; 牛楠; 孙丽莎; 陈光磊; 张董晓; 裴晓华; 冷锦红; 高允海; 路金才; 韩凌; 王亮; 赵玉虹; 刘彩刚

doi:10.16025/j.1674-1307.2025.06.007

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基于“郁毒致虚”理论探讨参百灵颗粒治疗乳腺癌癌因性疲乏的机制

专题——乳腺疾病的中医药诊疗 | 更新时间：2025-08-04

- 基于“郁毒致虚”理论探讨参百灵颗粒治疗乳腺癌癌因性疲乏的机制
- Mechanism of Shenbailing Granules in treating cancer-related fatigue in patients with breast cancer based on the theory of "depression and toxin leading to deficiency"
- 北京中医药 2025年44卷第6期页码：705-711
- 作者机构：
  
  1.中国医科大学附属盛京医院肿瘤中心，沈阳 110004
  2.首都医科大学附属北京中医医院乳腺科，北京 100010
  3.北京中医药大学第三附属医院乳腺科，北京 100029
  4.辽宁中医药大学附属医院国医大师张静生教授传承;工作室，沈阳 110032
  5.辽宁中医药大学附属医院普外科，沈阳 110032
  6.沈阳药科大学，本溪 117004
  7.华润三九医药股份有限公司，深圳 518110
  8.中国医科大学附属盛京医院辽宁省重大慢性疾病精准医学研究重点;实验室，沈阳 110004
- 作者简介：
  
  高晓宇，女，36岁，博士，副教授、副主任医师。研究方向：中西医结合防治肿瘤及心脑血管疾病。
  刘彩刚，E-mail：liucg@sj-hospital.org
- 基金信息：
  
  2022年沈阳市公共卫生研发专项医工结合项目(22-321-32-18);辽宁省中医药创新团队项目(LNZYYCXTD-JCCX-001)
- DOI：10.16025/j.1674-1307.2025.06.007
  中图分类号：
- 收稿日期：2025-01-06，
  
  纸质出版日期：2025-06-25
- 稿件说明：
移动端阅览
高晓宇，牛楠，孙丽莎，等.基于“郁毒致虚”理论探讨参百灵颗粒治疗乳腺癌癌因性疲乏的机制［J］.北京中医药，2025，44（6）：705-711.

GAO Xiaoyu,NIU Nan,SUN Lisha,et al.Mechanism of Shenbailing Granules in treating cancer-related fatigue in patients with breast cancer based on the theory of "depression and toxin leading to deficiency"[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(06):705-711.
高晓宇，牛楠，孙丽莎，等.基于“郁毒致虚”理论探讨参百灵颗粒治疗乳腺癌癌因性疲乏的机制［J］.北京中医药，2025，44（6）：705-711. DOI： 10.16025/j.1674-1307.2025.06.007.

GAO Xiaoyu,NIU Nan,SUN Lisha,et al.Mechanism of Shenbailing Granules in treating cancer-related fatigue in patients with breast cancer based on the theory of "depression and toxin leading to deficiency"[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(06):705-711. DOI： 10.16025/j.1674-1307.2025.06.007.

摘要

癌因性疲乏是乳腺癌患者最常见的症状之一，且持续时间长，严重影响患者生活质量。刘彩刚教授师承张静生国医大师，提出乳腺癌“郁毒致虚”理论，推崇中医理论指导下的现代医学精准诊疗理念。根据“郁毒致虚”理论，癌因性疲乏的发病机制可概括为“郁为因、毒为源、虚为果”，临床治疗需综合疏解“郁态”、清消“毒态”和培补“虚态”。鉴于癌因性疲乏的多系统和多靶点协同致病特性，刘彩刚教授提出了“多靶点网络调控”理论，构建了肿瘤免疫知识图谱，并研发了参百灵颗粒。通过中药多成分、多靶点、多层次的网络调控，实现对靶向神经-内分泌轴失衡、免疫-炎症轴异常、能量-代谢轴紊乱的微观调控。这种宏观与微观相结合的精准治疗策略，旨在有效缓解癌因性疲乏，改善乳腺癌患者的生存质量。

Abstract

Cancer-related fatigue is the most common and long-lasting symptom in breast cancer patients， seriously affecting their quality of life. Professor LIU Caigang， an apprentice of traditional Chinese medicine （TCM） master ZHANG Jingsheng， proposed the theory of "depression and toxin leading to deficiency" in breast cancerand advocates the concept of precise diagnosis andtreatment of modern medicine guided by TCM theory. According to this theory， the pathogenesis of cancer-related fatigue can be summarized as "depression as the cause， toxin as the source， and deficiency as the result". Clinical treatment should comprehensively relieve "depressive state"， clear and eliminate the "toxic state"， and tonify the "deficient state". In view of the multi-system and multi-target synergistic pathogenic characteristics of cancer-related fatigue， Professor LIU proposed the theory of "multi-target network regulation"，constructed a tumor immune knowledge map， and developed

Shenbailing Granules

. Through the multi-component， multi-target， and multi-level network regulation of Chinese medicine， micro-level regulation targeting imbalances in the neuroendocrine axis， immune-inflammatory axis， and energy-metabolism axis can be achieved. This precise treatment strategy， combining macro- and micro-level approaches， aims to effectively alleviate cancer-related fatigue and improve the quality of life of breast cancer patients.

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references

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