Objective

2

To observe the clinical efficacy and safety of the external application of

Cangfu Lotion

with dry tissues， a traditional Chinese medicine （TCM） formula based on the experience of renowned physician ZHAO Bingnan， in the treatment of tinea manuum and pedis.

Methods

2

A prospective， randomized， controlled study was

conducted involving 144 patients with tinea manuum and pedis treated at the Dermatology Outpatient Department of Beijing Hospital of Traditional Chinese Medicine from January 2022 to December 2023. Patients were randomly assigned by a random number table to Group A， Group B， or Group C. Group A was treated with

Cangfu Lotion

decoction soaking， Group B received dry tissues soaked in

Cangfu Lotion

for daily application， and Group C was treated with topical terbinafine cream. Each group underwent treatment for one week per course， for two consecutive courses. The efficacy was compared among the three groups by evaluating lesion area， itching severity score， lesion severity score， fungal clearance rate， adverse reactions， and recurrence rate before and after treatment.

Results

2

There was no statistically significant difference in the total effective rate among the three groups （

P

>

0.05）. After treatment， lesion area， itching severity score， and lesion severity score were significantly improved in all three groups compared to those before treatment （

P

<

0.01）. Significant differences were found among the three groups in lesion area and lesion severity score after treatment （

P

<

0.05）. Pairwise comparison showed that the lesion area in Group A was smaller than that in Group B （

P

<

0.05）， and lesion severity scores in Groups A and B were lower than those in Group C （

P

<

0.01）. No statistically significant differences were found among the groups in fungal clearance rate or incidence of adverse reactions. Recurrence rates in Groups A and B were lower than in Group C， but the difference was not statistically significant （

P

>

0.05）.

Conclusion

2

External application of

Cangfu Lotion

is effective and safe in treating tinea manuum and pedis. The patented dry tissue technology applied in TCM external treatment i

mproves convenience and portability.