Objective

2

To observe the clinical efficacy of modified

Cangfu Daotan Pills

combined with western medicine in the treatment of non-alcoholic steatohepatitis （NASH） with phlegm-turbid internal obstruction syndrome.

Methods

2

Ninety-six patients diagnosed with phlegm-turbid internal obstruction type NASH atThe First People’s Hospital of Huzhoufrom January 2022 to December 2023 were randomly divided into a control group and an observation group according to the random number table method， with 48 cases in each group. The control group received o

ral polyene phosphatidylcholine capsules （2 capsules per dose， three times daily）. The observation group was given modified

Cangfu Daotan Pills

granules in addition to the control group treatment， administered once daily. The treatment duration for both groups was 12 weeks. Biochemical indices （ALT， AST， GGT， TC， TG）， liver fat content ［controlled attenuation parameter （CAP）

value

2

， traditional Chinese medicine （TCM） syndrome scores， efficacy of liver fat content， TCM syndrome efficacy， and safety of the two groups were compared before and after treatment.

Results

2

After 12 weeks of treatment， biochemical indices in both groups were significantly decreased compared to baseline （

P

<

0.05）， with GGT， TC， and TG levels in the observation group significantly lower than those in the control group （

P

<

0.05）. CAP values decreased significantly in both groups after treatment （

P

<

0.05）， with the observation group showing lower CAP values than the control group. The total effective rate of liver fat content improvement was higher in the observation group than in the control group （

P

<

0.05）. TCM syndrome scores were significantly reduced in both groups after treatment （

P

<

0.05）， with the observation group scoring lower than the control group （

P

<

0.05）. The total effective rate of TCM syndrome treatment was 95.8% in the observation group， higher than 81.3% in the control group （

χ

2

=5.031，

P

<

0.05）. Safety indicators showed no abnormalities in either group， and no adverse symptoms such as fever， rash， nausea， or vomiting were observed during treatment.

Conclusion

2

Modified

Cangfu Daotan Pills

combined with Western medicine can improve liver function， reduce liver fat content， and alleviate TCM syndromes in patients with phlegm-turbid internal obst

ructiontype NASH， with a high safety profile.