Observe To observe the clinical efficacy and safety of

Wenwe

i

Mixture

in the treatment of functional abdominal pain （spleen deficiency and

qi

stagnation syndrome） in children.

Methods

2

A total of 72 children with functional abdominal pain （spleen deficiency and

qi

stagnation syndrome） who visited the outpatient department of Beijing Children's Hospital， Capital Medical University， from July 2022 to December 2023 were selected. The children were randomly divided into an observation group and a control group using a random number table. The observation group was treated with

Wenwe

i

Mixture

， while the control group was treated with omeprazole enteric-coated tablets. Both groups received treatment for 4 weeks. The improvement of the main symptoms， including traditional Chinese medicine （TCM） syndrome score， frequency of abdominal pain， duration of abdominal pain， NRS score， after treat

ment was observed， and the total effective rate， recurrence rate， and safety of the two groups were compared.

Results

2

After 4 weeks of treatment， the main symptom scores and total TCM syndrome scores of both groups were significantly reduced compared to those before treatment （

P

<

0.05）， with the observation group showing a greater reduction in the duration of abdominal pain， NRS score， and total TCM syndrome score than the control group （

P

<

0.05）. After 2 and 4 weeks of treatment， the total effective rate of the observation group was significantly higher than that of the control group （

P

<

0.05）. The total effective rate of the observation group at 4 weeks was higher than that at 2 weeks （

P

<

0.05）. The recurrence rate in the observation group was 6.25% （2 cases）， while the control group had a recurrence rate of 42.11% （8 cases）. The recurrence rate in the observation group was significantly lower than that in the control group （

P

<

0.05）. Four weeks after stopping the medication， the observation group showed significantly lower scores for frequency of abdominal pain， duration of abdominal pain， and NRS score compared to the control group （

P

<

0.05）. During the medication and follow-up period， both groups showed normal general vital signs， with no significant drug-related adverse reactions such as rashes， nausea， or vomiting. Blood， urine， and stool tests performed after the treatment showed no significant abnormalities.

Conclusion

2

Wenwe

i

Mixture

is highly effective in treating functional abdominal pain （spleen deficiency and

qi

stagnation syndrome） in children. It can significantly improve clinical symptoms， reduce recurrence rates， and has a high safety profile.