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1.首都医科大学附属北京中医医院,北京 100010
2.首都医科大学中医药学院,北京 100069
3.高益民名老中医工作室北京龙华中医门诊部分站,北京 100006
李姝凝,女,23岁,硕士研究生。研究方向:中医药实验和文献研究。
迟莉,E-mail:chili@ccmu.edu.cn
收稿日期:2024-08-02,
纸质出版日期:2025-08-25
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李姝凝,王文娟,高琦,等.高益民治疗系统性红斑狼疮经验[J].北京中医药,2025,44(8):1019-1022.
LI Shuning,WANG Wenjuan,GAO Qi,et al.GAO Yimin's experience in treating systemic lupus erythematosus[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(08):1019-1022.
李姝凝,王文娟,高琦,等.高益民治疗系统性红斑狼疮经验[J].北京中医药,2025,44(8):1019-1022. DOI: 10.16025/j.1674-1307.2025.08.014.
LI Shuning,WANG Wenjuan,GAO Qi,et al.GAO Yimin's experience in treating systemic lupus erythematosus[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(08):1019-1022. DOI: 10.16025/j.1674-1307.2025.08.014.
系统性红斑狼疮是自身免疫性疾病,高益民教授认为系统性红斑狼疮的发病主要是先天禀赋不足,外感邪毒,热毒入血,瘀阻脉络,内伤脏腑,外阻肌肤,其基本病机为“血热瘀滞,正虚邪恋”。该病分为急性期、慢性期两个阶段,并按照热毒、血瘀、正虚三证辨治,急性期多热毒证,慢性期多血瘀证与正虚证。治疗时将辨病与辨病证相结合,以玉屏风散、当归补血汤、秦艽丸合方作为基础方,并随症加减使用凌霄花、夏天无、白屈菜、冬凌草等药物。此外,高益民教授在治疗过程中强调扶正祛邪,根据患者正邪盛衰的具体情况随时调整用药,同时对于女性患者需结合月经的情况进行辨治。
Systemic lupus erythematosus is an autoimmune disease. Professor GAO Yimin believes that the pathogenesis of systemic lupus erythematosus is primarily due to congenital insufficiency, external inv
asion of pathogenic toxins, heat toxins entering the blood, blood stasis obstructing the vessels, internal injury of
zangfu
organs, and external obstruction of the skin. The fundamental pathogenesis is "blood heat stasis, healthy
qi
deficiency, and pathogen lingering". The disease is divided into two stages: the acute phase and the chronic phase. Differentiation and treatment are based on the three syndromes of heat toxicity, blood stasis, and healthy
qi
deficiency. The acute phase is predominantly characterized by heat toxicity, while the chronic phase is characterized by blood stasis and healthy
qi
deficiency. In treatment, Professor GAO combines disease differentiation with syndrome differentiation, using basic prescriptions such as
Yupingfeng Powder
,
Danggui Buxue Decoction
, and
Qinjiao Pills
, with modifications using herbs like
Campsis Flos
,
Corydalis Decumbentis Rhizoma
,
Chelidonii Herba
, and
Rabdosiae Rubescentis Herba
according to the patient's symptoms. Furthermore, Professor GAO emphasizes reinforcing the healthy
qi
and eliminating pathogenic factors during treatment, adjusting medications based on the specific situation of the patient's healthy
qi
and pathogenic
qi
fluctuations, and paying particular attention to the differentiation and treatment of female patients, incorporating their menstrual conditions.
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刘伟 , 杨梅 , 董振华 . 董振华治疗类风湿关节炎经验 [J ] . 北京中医药 , 2024 , 43 ( 6 ): 661 - 663 .
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殷小倩 , 卢璐 , 于俊生 . 中药凌霄花在慢性肾脏病中的临床应用概述 [J ] . 黑龙江中医药 , 2016 , 45 ( 6 ): 78 - 79 .
GHASHGHAEINIA M , KORALKOVA P , GIUSTARINI D , et al . The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis [J ] . Apoptosis , 2020 , 25 ( 9-10 ): 674 - 685 .
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