Objective

2

To observe the clinical efficacy of

Chaihu Guizhi Ganjiang Decoction

combined with

Zhizhu Decoction

in the treatment of type 2 diabetes mellitus （T2DM） with liver heat and spleen deficiency syndrome.

Methods

2

Sixty-four patients with T2DM characterized by liver heat and spleen deficiency who attended the endocrinology outpatient clinic or ward of Yuquan Hospital， Tsinghua University （Tsinghua University Hospital of Integrated Traditional Chinese and Western Medicine） from October 2023 t

o August 2024 were enrolled and were randomly divided into a control group and an observation group， with 32 patients in each group， using the random number table method. Both groups received diabetes health education and oral treatment with metformin hydrochloride tablets and dapagliflozin tablets. The observation group additionally received oral

Chaihu Guizhi Ganjiang Decoction

combined with

Zhizhu Decoction

. Both groups were treated continuously for 8 weeks. Clinical efficacy， traditional Chinese medicine （TCM） syndrome scores， glucose metabolism indicators ［fasting blood glucose （FBG）， 2-hour postprandial blood glucose （2 h PBG）， glycated hemoglobin （HbA

1

c）］， lipid metabolism indicators ［total cholesterol （TC）， triglycerides （TG）， low-density lipoprotein cholesterol （LDL-C）， high-density lipoprotein cholesterol （HDL-C）］， fasting insulin （FINS）， insulin resistance index （HOMA-IR）， and pancreatic β-cell function index （HOMA-β） were compared before and after treatment. Adverse reactions during the treatment period were recorded.

Results

2

The total effective rate in the observation group was 93.75%， higher than 75% in the control group （

P

<

0.05）. After treatment， TCM syndrome scores in both groups were lower than those before treatment （

P

<

0.05）， and scores in the observation group were lower than those in the control group （

P

<

0.05）. Levels of FBG， 2 hPBG， and HbA

1

c decreased in both groups after treatment （

P

<

0.05）， with greater reductions in the observation group （

P

<

0.05）. HOMA-IR decreased while HOMA-β increased in both groups after treatment （

P

<

0.05）. The observation group had lower HOMA-IR and higher HOMA-β values than the control group （

P

<

0.05）. Levels of TC， TG， and LDL-C decreased in both groups after treatment （

P

<

0.05）， with lower values in the obser

vation group compared to the control group （

P

<

0.05）. No adverse reactions were observed in either group during the treatment period.

Conclusion

2

Oral administration of

Chaihu Guizhi Ganjiang Decoction

combined with

Zhizhu Decoction

can improve clinical symptoms， regulate glucose and lipid metabolism， reduce insulin resistance， and enhance pancreatic β-cell function in patients with T2DM with liver heat and spleen deficiency syndrome.