Chuangzhen

is the collective term for infectious exanthematous skin diseases. QIAN Yi believed that the etiology of

Chuangzhen

lies in the internal accumulation of toxins and external exposure to wind and cold. Before the eruption of

Chuangzhen

， signs corresponding to the

Wuzang

organs can be observed； after eruption， each

zang

organ manifests a distinct symptom， specifically， blisters for the liver， pustules for the lung， spots for the heart， rashes for the spleen， and darkening for the kidney. Based on this， he proposed differentiating and treating

Chuangzhen

according to

Wuzang

organs. QIAN Yi advocated differentiating

Chuangzhen

and typhoid fever from the perspective of the five elements' generation， restraint， and transformation， emphasizing assessment of severity and order of progression. In treatment， both warm- and cool-natured drugs were used. He established three therapeutic methods： dispersion to promote eruption of

Chuangzhen

， "relief" to clear heat and remove toxin， and "purgation" to promote urination. He emphasized careful application， avoiding indiscriminate dispersion or purgation， while also paying attention to prognosis， preventing complications， and protecting the spleen and kidneys. QIAN Yi's academic thought on differentiation and treatment of

Chuangzhen

based on

Wuzang

organs had a significant impact on later generations of physicians and continues to provide a valuable reference for the diagnosis and treatment of infectious skin diseases today.