Objective

2

To observe the effects of

Xiaozhang Paste

on

Shenque

on inflammatory response， coagulation function， and intestinal mucosal injury in septic rats.

Methods

2

Sixty rats were randomly divided into five groups （

n

=12 each） using a random number table， including blank control group， model group， low-dose

Xiaozhang Paste

group， medium-dose

Xiaozhang Paste

group， and high-dose

Xiaozhang Paste

group. Sepsis was induced in all groups except the blank control group. All rats were shaved on the abdomen， and

Xiaozhang Paste

was applied to the

Shenque

acupoint at low， medium， and high doses in the corresponding groups. The model and blank control groups received a starch paste applied to the

Shenque

acupoint. Paste was replaced every 24 hours for a total of 72 hours. General condition， serum levels of tumor necrosis factor-α （TNF-α）， interleukin-1β （IL-1β）， interleukin-6 （IL-6）， activated partial thromboplastin time （APTT）， and pathological changes in intestinal tissue were compared among groups.

Results

2

The mortality of rats in the

Xiaozhang Paste

groups was lower than that in the model group， with higher doses corresponding to lower mortality. Compared with the blank control group， the model group showed significantly higher TNF-α， IL-1β， IL-6 levels （

P

<

0.01）， prolonged APTT

（

P

<

0.01）， and higher intestinal pathological scores （

P

<

0.01）. Compared with the model group， all

Xiaozhang Paste

groups had significantly lower TNF-α， IL-1β， IL-6 levels （

P

<

0.01）， shorter APTT （

P

<

0.05）， and lower intestinal pathological scores （

P

<

0.05）.

Conclusion

2

Xiaozhang Paste

on

Shenque

can reduce inflammatory responses， improve coagulation function， and alleviate intestinal mucosal injury in septic rats.