何成诗基于“补肾壮骨”辨治慢性阻塞性肺疾病相关的气管支气管软化症经验

周鹏程; 沈峻如; 余薇; 何成诗

doi:10.16025/j.1674-1307.2026.04.013

您当前的位置：

首页 >

文章列表页 >

何成诗基于“补肾壮骨”辨治慢性阻塞性肺疾病相关的气管支气管软化症经验

名医经验 | 更新时间：2026-06-10

- 何成诗基于“补肾壮骨”辨治慢性阻塞性肺疾病相关的气管支气管软化症经验
- Experience of HE Chengshi in differentiating and treating chronic obstructive pulmonary disease-associated tracheobronchomalacia from the perspective of tonifying the kidney and strengthening the bone
- 北京中医药 2026年45卷第4期页码：493-498
- 作者机构：
  
  1.成都中医药大学附属医院呼吸内科，成都 610072
  2.成都中医药大学临床医学院，成都 610072
- 作者简介：
  
  周鹏程，男，39岁，博士，副主任医师。研究方向：慢性阻塞性肺病、肺癌、良恶性中央气道狭窄的中西医结合基础与临床研究。
  何成诗，E-mail：hcs6512@126.com
- 基金信息：
  
  国家自然科学基金项目(81904177);四川省科技厅课题(2021YJ0465);四川省医学科研青年创新课题(Q23035);成都中医药大学“杏林学者”学科人才科研提升计划课题(QJRC2023004);成都中医药大学附属医院科技发展课题(22ZL03)
- DOI：10.16025/j.1674-1307.2026.04.013
  中图分类号：
- 收稿：2025-03-12，
  
  纸质出版：2026-04-25
- 稿件说明：
移动端阅览
周鹏程，沈峻如，余薇，等.何成诗基于“补肾壮骨”辨治慢性阻塞性肺疾病相关的气管支气管软化症经验［J］.北京中医药，2026，45（4）：493-498.

ZHOU Pengcheng,SHEN Junru,YU Wei,et al.Experience of HE Chengshi in differentiating and treating chronic obstructive pulmonary disease-associated tracheobronchomalacia from the perspective of tonifying the kidney and strengthening the bone[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(04):493-498.
周鹏程，沈峻如，余薇，等.何成诗基于“补肾壮骨”辨治慢性阻塞性肺疾病相关的气管支气管软化症经验［J］.北京中医药，2026，45（4）：493-498. DOI： 10.16025/j.1674-1307.2026.04.013.

ZHOU Pengcheng,SHEN Junru,YU Wei,et al.Experience of HE Chengshi in differentiating and treating chronic obstructive pulmonary disease-associated tracheobronchomalacia from the perspective of tonifying the kidney and strengthening the bone[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(04):493-498. DOI： 10.16025/j.1674-1307.2026.04.013.

摘要

慢性阻塞性肺疾病相关的气管支气管软化症是一种临床常见但易漏诊误诊的良性中央气道狭窄性疾病，主要由气道软骨软弱，不能支撑正常的管腔结构引起。何成诗教授基于临床经验认为，该病基本病机为肺肾亏虚、骨软气陷，从“补肾壮骨”的角度出发，确立了肺肾同治、壮骨填精、健脾养肝、活血化痰的主要治法，以经验方调补肺肾方为基础，灵活化裁，临床收效明显，为慢性阻塞性肺疾病相关的气管支气管软化症提供了新的诊治思路。

Abstract

Tracheobronchomalacia associated with chronic obstructive pulmonary disease （COPD） is a common but easily overlooked and misdiagnosed benign central airway stenotic disease， mainly caused by weakened airway cartilage that is unable to support the normal airway lumen structure. Professor HE Chengshi， based on his clinical experience， believes that the fundamental pathogenesis of this disease is deficiency of the lung and kidney， accompanied by bone weakness and sinking of

. From the perspective of "tonifying the kidney and strengthening the bone"， he established the principal therapeutic methods of simultaneous treatment of the lung and kidney， strengthening bones and replenishing essence， invigorating the spleen and nourishing the li

ver， and promoting blood circulation and resolving phlegm. Based on the empirical

Tiaobu Feishen Formula

and through flexible modifications according to clinical presentation， Professor HE Chengshi has achieved remarkable clinical efficacy， providing a new approach for the diagnosis and treatment of COPD-associated tracheobronchomalacia.

关键词

Keywords

references

ZHOU P , YU W , ZHANG W , et al . COPD-associated expiratory central airway collapse: current concepts and new perspectives [J ] . Chest , 2025 , 167 ( 4 ): 1024 - 1043 .

ERNST A , ODELL DD , MICHAUD G , et al . Central airway stabilization for tracheobronchomalacia improves quality of life in patients with COPD [J ] . Chest , 2011 , 140 ( 5 ): 1162 - 1168 .

陈典 , 隆寰宇 , 李姝润 , 等 . 2024年GOLD慢性阻塞性肺疾病诊断、治疗、管理及预防全球策略更新要点解读 [J ] . 中国全科医学 , 2024 , 27 ( 13 ): 1533 - 1543,1567 .

周鹏程 , 夏前明 , 余薇 , 等 . 慢性阻塞性肺疾病相关性气管支气管软化症诊治进展 [J ] . 中国呼吸与危重监护杂志 , 2022 , 21 ( 11 ): 820 - 826 .

何雯青 , 王佳佳 , 谢洋 , 等 . 慢性阻塞性肺疾病疾病负担测评方法概述 [J ] . 中国卫生经济 , 2024 , 43 ( 2 ): 58 - 61,66 .

WANG C , XU J , YANG L , et al . Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study [J ] . Lancet , 2018 , 391 ( 10131 ): 1706 - 1717 .

HEUSSEL CP , LEY S , BIEDERMANN A , et al . Respiratory lumenal change of the pharynx and trachea in normal subjects and COPD patients: assessment by cine-MRI [J ] . Eur Radiol , 2004 , 14 ( 12 ): 2188 - 2197 .

方晗语 , 冯沁祺 , 张洪春 . 基于肺肾相关理论治疗慢性阻塞性肺疾病稳定期研究进展 [J ] . 北京中医药 , 2021 , 40 ( 6 ): 681 - 684 .

窦进 , 郭珺 . 许彭龄补虚通滞法治疗慢性阻塞性肺疾病急性加重期经验 [J ] . 北京中医药 , 2021 , 40 ( 6 ): 598 - 599 .

张亚达 , 姚亮 , 王振伟 , 等 . 金水相生法治疗慢性阻塞性肺疾病稳定期肺肾两虚证研究进展 [J ] . 实用临床医药杂志 , 2019 , 23 ( 8 ): 119 - 122,127 .

BHATT SP , TERRY NL , NATH H , et al . Association between expiratory central airway collapse and respiratory outcomes among smokers [J ] . JAMA , 2016 , 315 ( 5 ): 498 - 505 .

陈维维 , 刘文礼 , 徐江雁 . 从“精不足者,补之以味”论述糖尿病肾脏疾病的辨治 [J ] . 中华中医药杂志 , 2023 , 38 ( 11 ): 5404 - 5406 .

LIU J , MENG Q , JING H , et al . Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation [J ] . Mol Med Rep , 2017 , 16 ( 3 ): 3269 - 3275 .

LEE JH , LIM H , SHEHZAD O , et al . Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation [J ] . Eur J Pharmacol , 2014 , 724 : 145 - 151 .

ZHAO Y , LI Z , WANG W , et al . Naringin protects against cartilage destruction in osteoarthritis through repression of NF-κB signaling pathway [J ] . Inflammation , 2016 , 39 ( 1 ): 385 - 392 .

ROHDEWALD PJ . Review on sustained relief of osteoarthritis symptoms with a proprietary extract from pine bark, pycnogenol [J ] . J Med Food , 2018 , 21 ( 1 ): 1 - 4 .

FENG S , CONG H , JI L . Salvianolic acid a exhibits anti-inflammatory and antiarthritic effects via inhibiting NF-κB and p38/MAPK pathways [J ] . Drug Des Devel Ther , 2020 , 14 : 1771 - 1778 .

XU XX , ZHANG XH , DIAO Y , et al . Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro [J ] . Kaohsiung J Med Sci , 2017 , 33 ( 2 ): 62 - 68 .

ALI A , PARK Y , LEE J , et al . In vitro study of licorice on IL-1β-induced chondrocytes and in silico approach for osteoarthritis [J ] . Pharmaceuticals (Basel) , 2021 , 14 ( 12 ): 1337 .

周鹏程 , 余薇 , 陈科伶 , 等 . 调补肺肾方对慢性阻塞性肺疾病合并气管支气管软化症患者肺功能和生活质量的影响 [J ] . 成都中医药大学学报 , 2019 , 42 ( 1 ): 45 - 50 .

ZHOU P , YU W , CHEN K , et al . Effect of the Tiaobufeishen decoction on caveolin-1-p38 MAPK signaling pathway and mechanism of improving the tracheobronchomalacia in chronic obstructive pulmonary disease [J ] . TMR Integr Med , 2019 , 3 : e19002 .

李雪莲 , 余薇 , 周鹏程 . 慢性阻塞性肺疾病相关性气管支气管软化症模型建立及评价 [J ] . 中国老年学杂志 , 2023 , 43 ( 24 ): 5971 - 5978 .

余薇 , 周鹏程 , 陈科伶 , 等 . 一种慢性阻塞性肺疾病合并气管支气管软化症模型制备方法及调补肺肾方干预效果评价 [J ] . 现代中西医结合杂志 , 2021 , 30 ( 10 ): 1040 - 1046 .

ZHOU P , YU W , ZHANG C , et al . Tiao-bu-fei-shen formula promotes downregulation of the caveolin 1-p38 mapk signaling pathway in COPD-associated tracheobronchomalacia cell model [J ] . J Ethnopharmacol , 2022 , 293 : 115256 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

刘瓦利从多角度辨证治疗顽固性痤疮经验

背俞穴皮内针埋针联合肺康复训练对慢性阻塞性肺疾病稳定期患者肺功能和生活质量的影响

武维屏用麦味五参汤加味治疗悸喘类慢性肺系疾病经验

基于“脏腑相关”探讨“肺-肠-脑轴”在慢性阻塞性肺疾病合并神志异常诊疗中的应用

张振宇精点力学四步手法结合运动康复治疗颈源性肩周痛经验