脾-肠道菌群与冠状动脉疾病合并认知障碍的关系及中医药的调控作用

杨晓鹤; 王雪森; 王佳; 高美丽; 谭曦轮; 钟升兵; 黄灿; 张辰浩

doi:10.16025/j.1674-1307.2026.02.017

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脾-肠道菌群与冠状动脉疾病合并认知障碍的关系及中医药的调控作用

学术探讨 | 更新时间：2026-04-08

- 脾-肠道菌群与冠状动脉疾病合并认知障碍的关系及中医药的调控作用
- Relationship between spleen-intestinal flora and CAD combined with cognitive impairment and regulation role of traditional Chinese medicine
- 北京中医药 2026年45卷第2期页码：239-245
- 作者机构：
  
  1.中国中医科学院望京医院感染科，北京 100102
  2.贵阳市妇幼保健院中医科，贵阳 550003
- 作者简介：
  
  杨晓鹤，女，29岁，博士研究生，住院医师。研究方向：中西医结合防治心血管疾病。
  张辰浩，E-mail：zhangch500@126.com
- 基金信息：
  
  首都卫生发展科研专项重大攻关项目(2022-1-4161);中国中医科学院望京医院高水平中医医院建设项目重点课题(WJYY-XZKT-2023-08)
- DOI：10.16025/j.1674-1307.2026.02.017
  中图分类号：
- 收稿：2025-02-18，
  
  纸质出版：2026-02-25
- 稿件说明：
移动端阅览
杨晓鹤，王雪森，王佳，等.脾-肠道菌群与冠状动脉疾病合并认知障碍的关系及中医药的调控作用［J］.北京中医药，2026，45（2）：239-245.

YANG Xiaohe,WANG Xuesen,WANG Jia,et al.Relationship between spleen-intestinal flora and CAD combined with cognitive impairment and regulation role of traditional Chinese medicine[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(02):239-245.
杨晓鹤，王雪森，王佳，等.脾-肠道菌群与冠状动脉疾病合并认知障碍的关系及中医药的调控作用［J］.北京中医药，2026，45（2）：239-245. DOI： 10.16025/j.1674-1307.2026.02.017.

YANG Xiaohe,WANG Xuesen,WANG Jia,et al.Relationship between spleen-intestinal flora and CAD combined with cognitive impairment and regulation role of traditional Chinese medicine[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(02):239-245. DOI： 10.16025/j.1674-1307.2026.02.017.

摘要

冠状动脉疾病和认知障碍共存是常见的临床现象。研究表明，肠道微生物群在代谢紊乱、神经退行性疾病和心血管疾病等疾病的发病过程中起着重要作用。中医学认为“脾”的生理功能与肠道菌群功能相似。以“健脾”为主的中药能够调节肠道菌群的功能和结构、减少炎症反应，对心血管疾病及神经系统疾病疗效确切。肠道菌群或成为治疗冠状动脉疾病合并认知障碍疾病的新切入点。

Abstract

The coexistence of coronary artery disease （CAD） and cognitive impairment is a common clinical phenomenon. Studies have shown that the intestinal flora plays an important role in the pathogenesis of diseases such as metabolic disorders， neurodegenerative diseases， and cardiovascular diseases. In traditional Chinese medicine （TCM）， the physiological functions of the "spleen" are considered similar to those of the intestinal flora. Chinese herbal medicines focusing on "strengthening the spleen" can regulate the function and structure of the intestinal flora， reduce inflammatory responses， and have demonstrated definite efficacy in the treatment of cardiovascular and neurological diseases. The intestinal flora may serve as a new entry point for the treatment of CAD complicated with cognitive impairment.

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