Oxidative stress mechanism of liver fibrosis from the perspective of Qi deficiency and collateral-stasis

Fu-dong LIU; Bo PANG; Wen-liang LYU; Rui QIANG

doi:10.16025/j.1674-1307.2022.06.013

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Oxidative stress mechanism of liver fibrosis from the perspective of Qi deficiency and collateral-stasis

更新时间：2023-02-15

- Oxidative stress mechanism of liver fibrosis from the perspective of Qi deficiency and collateral-stasis
- Beijing Journal of Traditional Chinese Medicine Vol. 41, Issue 6, Pages: 634-636(2022)
- 作者机构：
  
  1.中国中医科学院广安门医院，北京 100053
  2.中国中医科学院广安门医院国际医疗部，北京 100053
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2022.06.013
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刘福栋，庞博，吕文良，等.从气虚络瘀角度探讨肝纤维化氧化应激机制［J］.北京中医药，2022，41（6）：634-636.

LIU Fu-dong,PANG Bo,LYU Wen-liang,et al.Oxidative stress mechanism of liver fibrosis from the perspective of Qi deficiency and collateral-stasis[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(06):634-636.
刘福栋，庞博，吕文良，等.从气虚络瘀角度探讨肝纤维化氧化应激机制［J］.北京中医药，2022，41（6）：634-636. DOI： 10.16025/j.1674-1307.2022.06.013.

LIU Fu-dong,PANG Bo,LYU Wen-liang,et al.Oxidative stress mechanism of liver fibrosis from the perspective of Qi deficiency and collateral-stasis[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(06):634-636. DOI： 10.16025/j.1674-1307.2022.06.013.

摘要

中医学认为，气虚络瘀是肝纤维化（HF）的核心病机。现代临床研究证实氧化应激与HF密切相关，其实质是氧化与抗氧化系统之间的失衡。气虚与络瘀、氧化与抗氧化机制之间存在相似性，氧化应激反应与肝络瘀阻、血行不利均可视为于邪气侵袭肝络，从而引起肝脏损伤；抗氧化系统减弱或缺陷与气虚均可看作于机体的修复、驱邪作用减弱，无力抗御损伤。基于此，提出治疗HF以益气逐瘀为基本治则的观点，使氧化应激反应趋于平衡稳定，临床收效显著。

Abstract

关键词

肝纤维化气虚血瘀氧化应激

Keywords

references

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